2025年3月30日 · MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with MALAT1 include Kidney Cancer and Ovary Epithelial Cancer .

MALAT1 is a highly conserved nuclear retained lncRNA that is abundantly expressed in cells and tissues and has been shown to play a role in regulating genes at both the transcriptional and post-transcriptional levels in a context-dependent manner. However, Malat1 has been shown to be dispensable for normal development and viability in mice.

2024年3月16日 · Nature Communications - MALAT1 is a long non-coding RNA that is known to suppress breast cancer lung metastasis. Here the authors show that MALAT1 is downregulated during osteoclastogenesis...

MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) also known as NEAT2 (Nuclear-Enriched Abundant Transcript 2) is an infrequently spliced long non-coding RNA, which is highly conserved amongst mammals and highly expressed in the nucleus. [3] It regulates the expression of metastasis-associated genes. [4]

Malat1 is one of the first identified lncRNAs associated with human disease, and cumulative studies have indicated that Malat1 plays critical roles in the development and progression of various cancers.

MALAT1 （metastasis associated lung adenocarcinoma transcript 1，人类肺腺癌转移相关转录本1），也叫做 NEAT2，长度为8779nt，定位于染色体11q13.1，是2003年首次报道的一种LncRNA。 MALAT1是哺乳动物中最保守的LncRNA之一，在正常组织细胞核中丰度较高。 MALAT1被发现在多种肿瘤组织中表达上调，对肿瘤细胞的增殖、迁移、侵袭和凋亡有促进作用， 自2003年发现以来，MALAT1通常被认为是促癌基因而被人们广泛研究，PubMed上的相关论 …

2024年1月9日 · In this study, we uncover a tumor cell-intrinsic, dose-dependent requirement for the long noncoding RNA (lncRNA) Malat1 in tumor initiation and metastatic reactivation. We link this requirement...

2018年10月22日 · These findings demonstrate that MALAT1 is a metastasis-suppressing lncRNA rather than a metastasis promoter in breast cancer, calling for rectification of the model for this highly abundant and...

2024年7月8日 · 转移相关肺腺癌转录本1（MALAT1）是最早发现的和进化上最保守的长非编码RNA（lncRNA）之一。 MALAT1在多种癌症中的表达水平显著升高，并在预测癌症转移和患者生存方面具有重要的临床应用意义【1】。 MALAT1在 乳腺癌 、 肝癌 和 肺癌 、 糖尿病 、胰岛素信号传导、炎症等疾病中发挥多种作用。 MALAT1定位于核斑点（nuclear speckles），直接与活性染色质和RNA结合蛋白（如异质性核核糖核蛋白C（hnRNP C）和丝氨酸/精氨酸剪接因子） …

Tripathi等通过RNA-FISH实验，使用MALAT1和U2-snRNA特异性探针和SR剪接因子抗体，证实核富集的MALAT1与丝氨酸精氨酸SR蛋白相互作用，影响剪接因子的配送等。 沉默MALAT1或过表达SR蛋白可以不同程度的改变内源性前mRNA的选择性剪接。