PINK1-AS Gene - PINK1 Antisense RNA - GeneCards
2024年12月25日 · PINK1-AS (PINK1 Antisense RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with PINK1-AS include Parkinson Disease 6, Autosomal Recessive Early-Onset and Glucose Metabolism Disease.
PINK1 - Wikipedia
PTEN -induced kinase 1 (PINK1) is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene. [5][6] It is thought to protect cells from stress-induced mitochondrial dysfunction.
Insulin signalling regulates Pink1 mRNA localization via ... - Nature
2024年3月19日 · In this study, we aimed to investigate how insulin and AMPK signalling regulate mitochondrial Pink1 mRNA localization and PINK1 function. We identified SYNJ2BP as a substrate of AMPK downstream of...
PINK1 Gene - GeneCards | PINK1 Protein | PINK1 Antibody
2024年12月25日 · PINK1 (PTEN Induced Kinase 1) is a Protein Coding gene. Diseases associated with PINK1 include Parkinson Disease 6, Autosomal Recessive Early-Onset and Early-Onset Parkinson's Disease. Among its related pathways are Gene expression (Transcription) and Selective autophagy.
PINK1 and Parkin Control Localized Translation of Respiratory Chain ...
2015年1月6日 · Translationally repressed nRCC mRNAs are localized in a PINK1/Tom20-dependent manner to mitochondrial outer membrane, where they are derepressed and activated by PINK1/Parkin through displacement of translation repressors, including Pumilio and Glorund/hnRNP-F, a Parkin substrate, and enhanced binding of activators such as eIF4G.
PINK1 and Parkin mitochondrial quality control: a source of …
2020年3月13日 · Loss of PINK1 in Drosophila neuromuscular tissue, human cell lines, and human DA neurons derived from patient iPSCs impairs localization of nc-mtRNAs to mitochondria, including several key ETC components, without affecting total RNA levels of …
Activation mechanism of PINK1 - Nature
2021年12月21日 · Mutations in the protein kinase PINK1 lead to defects in mitophagy and cause autosomal recessive early onset Parkinson’s disease 1, 2. PINK1 has many unique features that enable it to phosphorylate...
Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 …
2022年5月4日 · Using live imaging of Pink1 mRNA, we observed cotransport of Pink1 mRNA with mitochondria and identified a tethering mechanism that uses the mitochondrial outer membrane protein synaptojanin 2 binding protein (SYNJ2BP) and a neuron-specific and RNA-binding splice isoform of synaptojanin 2 (SYNJ2a).
PINK1/PARKIN signalling in neurodegeneration and neuroinflammation ...
2020年11月9日 · PINK1, a protein kinase, and PARKIN, an E3 ubiquitin ligase, control the specific elimination of dysfunctional or superfluous mitochondria, thus fine-tuning mitochondrial network and preserving energy metabolism.
Generation and Application of Mouse-Rat Allodiploid Embryonic Stem ...
2016年1月14日 · (E) RNA-FISH analysis of mouse Xist (pink) and rat Xist (cyan) expression in EF isolated from RM1-1 and MR1-1 AdESC-derived mouse E13.5 embryos. Nuclei (blue) are stained with Hochest33342.