The RNA-induced silencing complex, or RISC, is a multiprotein complex, specifically a ribonucleoprotein, which functions in gene silencing via a variety of pathways at the …

On the molecular level, RNA interference is mediated by a family of ribonucleoprotein complexes called RNA-induced silencing complexes (RISCs), which can be programmed to target virtually …

RNA-induced silencing complex, or RISC, is a multiprotein complex that incorporates one strand of a small interfering RNA (siRNA) or micro RNA (miRNA). RISC uses the siRNA or miRNA as …

2022年1月6日 · To achieve these functions, small RNAs form RNA-induced silencing complex (RISC) together with a member of the Argonaute (AGO) protein family. RISC is directed by its …

RNA-induced silencing complex (RISC) is one of the basic eukaryotic cellular machinery which plays a pivotal role in post-transcriptional gene regulation. Discovery of miRNAs and their role …

Heterochromatin formation in fission yeast relies on the RNA interference pathway and in particular on a complex of proteins called RITS (RNA-induced initiation of transcriptional gene …

2005年1月14日 · In the RNA-interference pathway, double-stranded RNA induces sequence-specific mRNA degradation through the action of the RNA-induced silencing complex (RISC).

2007年2月20日 · The purpose of this brief review is to highlight key achievements in elucidating the biochemical mechanisms of the RNA-induced silencing complex and to outline major …

2024年8月10日 · The RNA-induced silencing complex (RISC) is a multiprotein complex that plays a central role in RNA interference (RNAi) and post-transcriptional gene silencing mechanisms. …

RNA-induced silencing complex (RISC) assembly and function can be divided into at least two catalytically controlled steps, and for simplicity only two kinetic checkpoints are considered.