RNA interference (RNAi) is a biological process in which RNA molecules are involved in sequence-specific suppression of gene expression by double-stranded RNA, through translational or transcriptional repression. Historically, RNAi was known by other names, including co-suppression, post-transcriptional gene silencing (PTGS), and quelling.

2017年11月9日 · RNA interference or Post-Transcriptional Gene Silencing is a conserved biological response to double-stranded RNA that mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and …

RNA干涉 (RNA interference，简称RNAi)是指一些小的双链RNA (double strand RNA, dsRNA)可以高效、 特异的阻断体内 特定基因表达,促使mRNA降解,诱使细胞表现出特定基因缺失的表型。

RNAi can be triggered by two different pathways: (i) an RNA-based approach where synthetic effector siRNAs are delivered by various carriers to target cells as preformed 21 base duplexes; or (ii) via DNA-based strategies in which the siRNA effectors are produced by intracellular processing of longer RNA hairpin transcripts (reviewed in ...

Double-stranded RNA-mediated interference (RNAi) is a simple and rapid method of silencing gene expression in a range of organisms. The silencing of a gene is a consequence of degradation of RNA into short RNAs that activate ribonucleases to target homologous mRNA.

2020年8月12日 · RNA interference (RNAi) is one of the pathways, collectively named RNA silencing pathways, that employ small RNAs as guides for sequence-specific silencing [reviewed in (Ketting, 2011)]. RNAi was discovered in C. elegans and defined as sequence-specific mRNA degradation induced by long double-stranded RNA (dsRNA) (Fire et al., 1998).

The three pathways of RNAi (miRNA, siRNA, piRNA) share a common mode of action: the minimal effector is an RNP complex comprising an Argonaute family protein bound to a single stranded ~20–30 nt RNA that grants specificity via base-pairing interactions with the gene target.

RNA interference pathway. The term RNA interference (RNAi) was coined to describe a cellular mechanism that uses the gene's own DNA sequence to turn it off, a process that researchers call silencing. In a wide variety of organisms, including animals, plants, and fungi, RNAi is triggered by double-stranded RNA (dsRNA).

2005年1月1日 · There is increasing evidence that RNA interference (RNAi)-mediated pathways have important roles in gene regulation at the nuclear-genome level. Key proteins of the RNAi machinery (Dicer,...

2024年10月2日 · RNA interference (RNAi) acts as a powerful defense mechanism against viruses and regulates gene expression. This intricate pathway is based on the ability of double-stranded RNA (dsRNA) molecules to trigger a silencing effect.