Ribonucleotide reductase (RNR), also known as ribonucleoside diphosphate reductase, is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides. [1][2] It catalyzes this formation by removing the 2'-hydroxyl group of the ribose ring of nucleoside diphosphates (or triphosphates depending on the class of RNR).

2004年6月1日 · Ribonucleotide reductase (RNR) is the enzyme responsible for the conversion of the four standard ribonucleotides, 5′-di (or tri)-phospho -adenosine, -cytidine, -guanosine, and -uridine, to their 2′-deoxyribonucleotide counterparts and thereby provides the precursors needed for both synthesis and repair of DNA.

RNR’s central role in nucleic acid metabolism has resulted in five therapeutics that inhibit human RNR. In this review we discuss the structural, dynamic, and mechanistic aspects of RNR activity and regulation, primarily for the human and E. coli class Ia enzymes.

2004年6月1日 · Ribonucleotide reductase (RNR) is the enzyme responsible for the conversion of ribonucleotides to 2'-deoxyribonucleotides and thereby provides the precursors needed for both synthesis and repair of DNA.

Ribonucleotide reductase (RNR) is a key enzyme that mediates the synthesis of deoxyribonucleotides, the DNA precursors, for DNA synthesis in every living cell. This enzyme converts ribonucleotides to deoxyribonucleotides, the building blocks for …

1998年8月7日 · The substrate mechanism of ribonucleotide reductase (RNR) is studied using a hybrid DFT method (B3LYP) with large basis sets. With models for the calculations based on recently determined X-ray structures, different mechanisms of the steps leading from a ribonucleotide to a deoxyribonucleotide are investigated.

在这里，我们提出了核糖核苷酸还原酶 (rnr) 的多学科讨论，rnr 是唯一负责将核糖核苷酸转化为脱氧核糖核苷酸的必需酶。 本章主要概述了这种多方面和复杂的酶，涵盖了 RNR 在酶学、生物化学、药物化学和细胞生物学中的作用。

2022年5月16日 · Ribonucleotide reductase (RNR) is an essential enzyme that catalyzes the synthesis of DNA building blocks in virtually all living cells. NrdR, an RNR-specific...

2001年11月1日 · Ribonucleotide reductase is a ubiquitous cytosolic enzyme with a key role in DNA synthesis as it catalyses the biosynthesis of deoxyribonucleotides. It performs this reaction with the help of organic free radicals, which are stored by the enzyme until required for catalysis, and a key element in catalysis is the control of the free radical.

2020年6月20日 · Ribonucleotide reductases (RNRs) catalyze the de novo conversion of nucleotides to deoxynucleotides in all organisms, controlling their relative ratios and abundance. In doing so, they play an important role in fidelity of DNA replication and repair.