ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. Other common names are ROKβ and P160ROCK. ROCK1 is a major downstream effector of the small GTPase RhoA and is a regulator of the actomyosin cytoskeleton which promotes contractile force generation. [5]

2024年12月25日 · ROCK1 (Rho Associated Coiled-Coil Containing Protein Kinase 1) is a Protein Coding gene. Diseases associated with ROCK1 include Breast Cancer and Lung Cancer. Among its related pathways are Semaphorin interactions and Activation of cAMP-Dependent PKA.

2017年6月10日 · rock1和rock2基因包含33个外显子，各自位于18q11和2p24染色体区域[1]。rock2除了全长转录体外，还有一种剪接突变体（mrock2）。mrock2在外显子27与28之间存在额外的外显子27＇，它的基因产物仍保留着rock活性，仅有微小的差别[2]。

Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in diverse cellular activities including actin cytoskeleton organization, cell adhesion and ...

2024年11月20日 · Ras同源基因家族蛋白A (Ras homolog gene family member A, RhoA)/Rho相关卷曲螺旋蛋白激酶(Rho - associated coiled - coil forming protein kinase,ROCK)信号通路是缺血性卒中病理过程中的重要调节因子,其中RhoA是Rho家族的小的鸟苷三磷酸(guanosine triphosphate, GTP)酶,可介导细胞间黏附和细胞 ...

2025年2月8日 · ROCK1 is a multifunctional factor maintaining the primordial follicle reserve and follicular development in mice. Inhibition of RhoA/ROCK signalling pathway activity improves neural damage and cognitive deficits in the fluorosis model. circROCK1 Promotes septic myocardial injury through regulating miR-96-5p/OXSR1 axis.

ROCK1，即Rho相关卷曲螺旋激酶1，别名Rho激酶1、ROK-β、p160-ROCK。 它是一种由ROCK1基因编码的丝氨酸/苏氨酸蛋白激酶，属于Rho/ROCK信号通路的关键组成部分。 ROCK1的作用机制主要是通过磷酸化多种底物蛋白，如肌球蛋白轻链、LIM激酶等，参与调节细胞形态、运动、收缩和增殖等生理过程。 ROCK1在调控细胞骨架重组、细胞迁移、血管内皮通透性以及组织收缩和生长等多种生理功能中发挥重要作用。 此外，ROCK1的功能异常与糖尿病肾病、眼疾 …

ROCK (Rho-associated protein kinase) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. ROCKs (ROCK1 and ROCK2) occur in mammals, zebrafish, Xenopus, invertebrates and chicken. Human ROCK1 has a molecular mass of 158 kDa and is a major downstream effector of the small GTPase RhoA.

rock1 升高导致丰富的细胞外 aβ 沉积，进而与 aβ 受体结合并激活 rhoa/rock1，从而形成 ad 发病机制的恶性循环。 基因下调 rock1 降低了其对 tfeb 的干扰，促进了 tfeb 核分布、溶酶体生物发生和溶酶体介导的 aβ 清除，并最终阻止了 app/ps1 小鼠的病理特征和认知缺陷。

rock是rho分子下游靶效应分子，具有两种同源异构体：rock1和rock2，rock1主要在人类的肾脏组织中表达。研究发现rock1基因的高表达存在与许多恶性肿瘤中，它与肿瘤的发生发展有着密切的关系，参与了许多肿瘤的进展过程并促进肿