2024年10月9日 · We identify macrophage inflammatory protein-1α (MIP-1α) and MIP-1β as key chemokines that induce Src-mediated tyrosine phosphorylation of A2, thus enabling …

Since A2-E was suggested to act as a proapoptotic molecule via a mitochondrial pathway, we postulate that upon reaching a critical intralysosomal concentration, A2-E is released from the …

The results in this study demonstrate that A2-E is phototoxic to human RPE cells confirming its potential as a significant contributor to the photoreactivity of lipofuscin. It appears that A2-E …

Internalization of A2E by the RPE cells was evidenced by the acquisition of intracellular granules detectable by fluorescence confocal imaging. Internalized A2E had an emission maxima of …

A2-E is detrimental to RPE cell function by a variety of mechanisms: inhibition of lysosomal degradative capacity, loss of membrane integrity, and phototoxicity. Such mechanisms could …

N-retinylidene-N-retinylethanolamine (A2E) is a by-product of the visual cycle formed by the reaction of 2 all-trans retinal molecules with phosphatidylethanolamine generating …

2003年12月1日 · A substantial portion of the lipofuscin that accumulates with age and in some retinal disorders in retinal pigment epithelial (RPE) cells, forms as a consequence of light …

2009年9月1日 · Here, we show that anx A2 is highly enriched on newly formed phagosomes in RPE cells and that siRNA-mediated depletion of anx A2 results in impairment of POS …

2006年11月1日 · Purpose: A2-E, a major component of the retinal pigment epithelium (RPE) lipofuscin, is a compound that can neither be degraded by nor eliminated from cells and is …

The lipofuscin that accumulates in retinal pigmented epithelial (RPE) 1 cells with age and in some retinal disorders is a complex mixture of fluorophores, some elements of which are derived …