2020年9月1日 · To overcome these issues, we developed methods for the generation of RPE sheets from hiPSC, and image-based evaluation. We found that stepwise treatment with six signaling pathway inhibitors...

Image 1. Right eye. Subretinal fluid and dense subretinal hemorrhage adjacent to an area of "scrolled" retinal pigment epithelium (RPE) temporally to nasally; long white arrows point to the temporal edge of a well-demarcated area that lacks RPE, as a result of it curling nasally (white arrow heads) toward the optic nerve.

2023年3月1日 · To image healthy retinal pigment epithelial (RPE) cells in vivo using Transscleral OPtical Imaging (TOPI) and to analyze statistics of RPE cell features as a function of age, axial length (AL), and eccentricity. Single-center, exploratory, prospective, and …

This work provides a complete reference map of human RPE subpopulations and their location in the eye. In addition, the analysis of cadaver non-AMD and AMD eyes and ultra-widefield fundus images of patients revealed differential vulnerability of the five RPE subpopulations to different retinal diseases.

The retinal pigment epithelium (RPE) layer is located between the neurosensory retina and the choroid. Its main functions are to supply the highly metabolically active retina with nutrients and remove waste products from the photosensory processes of the cones and rods.

2017年3月15日 · Human RPE cells contain abundant organelles of imaging significance including lipofuscin, melanolipofuscin, melanosomes, and mitochondria. Autofluorescence and reflectivity of these organelles allow RPE visualization in laboratory and clinical settings.

2022年10月1日 · Objective To image healthy retinal pigment epithelial cells (RPE) in vivo using Transscleral OPtical Imaging (TOPI) and to analyze statistics of macular RPE cell features as a function of...

In this study, we used adaptive optics optical coherence tomography (AO-OCT) in conjunction with organelle motility as a novel contrast mechanism to visualize RPE cells and characterize their 3-dimensional (3D) reflectance profile.

2022年7月1日 · To address this challenge, we develop a novel method (MultiHeadGAN) for segmenting RPE cells from 2D RPE flatmount microscopy images in this study. Our developed method takes a semi-supervised learning strategy and enables deep neural networks to learn from a small set of annotated and a large set of unlabeled image data, resulting in a more ...

Transplantation of retinal pigment epithelial (RPE) sheets derived from human induced pluripotent cells (hiPSC) is a promising cell therapy for RPE degeneration, such as in age-related macular degeneration.