2017年3月16日 · We assessed the feasibility of transplanting a sheet of retinal pigment epithelial (RPE) cells differentiated from induced pluripotent stem cells (iPSCs) in a patient with neovascular...

2021年11月2日 · The use of an RPE sheet allows visual confirmation of placement, but the preparation of a sheet requires considerable time and cost, and involves an invasive surgical procedure requiring a...

2024年1月16日 · Retinal pigment epithelium (RPE) cell therapy is a promising way to treat many retinal diseases. However, obtaining transplantable RPE cells is time-consuming and less effective. This study aimed to develop novel strategies for generating engineered RPE patches with physiological characteristics.

2024年12月1日 · This article reviews the research conducted on RPE cell sheets, explores the progress of RPE sheets in treating RD, and discusses the current status of research on tissue-engineered RPE cell sheets.

2016年10月11日 · Retinal pigment epithelium (RPE) cells are an especially safe cell type that will seldom form tumors; however, a major problem using autologous iPSCs for standard treatment is the high cost of cell production. To resolve these issues, we are studying allogeneic retinal cell lines derived from iPSCs.

In vitro generation of a functional retinal pigment epithelium (RPE) monolayer sheet is useful and promising for RPE cell therapy. Here, we outline a method to construct engineered RPE sheets treated by induced pluripotent stem cell-conditioned medium (iPS-CM) in conjunction with femtosecond laser i …

2019年7月1日 · Here, we constructed engineered RPE sheets treated by iPS-CM in conjunction with FLI-lenticule scaffolds to help in enhanced RPE characteristics and cilium assembly. Such a strategy to generate RPE sheets is a promising avenue for developing RPE cell therapy, disease models and drug screening tools.

Retinalpigment epithelium (RPE) sheets or RPE suspensions are used for wet-type age-related macular degeneration (AMD) according to the activity levels of exudative changes (A).

A comparison of autologous transplantation of retinal pigment epithelium (RPE) monolayer sheet graft with RPE-Bruch's membrane complex graft in neovascular age-related macular degeneration.

2015年1月1日 · In this study, we hypothesized increased variability in the shape and size of RPE cells and increased spatial irregularity by: (1) region-, (2) age-, and (3) disease. To test this hypothesis, we analyzed RPE cell shape and size from human cadaveric eyes .