We propose that the third hyper-reflective band in the porcine retina was generated by the extensive membranous profiles associated with the overlapping RPE apical cell processes and...

The RPE is a low cuboidal epithelium containing very long sheet-like apical microvilli that project into the interphotoreceptor matrix. The microvilli interact with the tips of the rod and cone photoreceptor outer segments extending from the outer retinal surface.

2016年6月9日 · Alterations in the morphology and function of the retinal pigment epithelium (RPE) are common features shared by many ocular disorders. We report a detailed protocol to collect, seed, culture...

2021年6月4日 · Epithelial–mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells plays a key role in proliferative retinal diseases such as age-related macular...

2021年8月2日 · To explore the temporal mitochondrial characteristics of retinal pigment epithelium (RPE) cells obtained from human embryonic stem cells (hESC)-derived retinal organoids (hEROs-RPE), to verify the optimal period for using hEROs-RPE as donor cells from the aspect of mitochondria and to optimize RPE cell-based therapeutic strategies for age ...

2024年10月19日 · RPE-specific ablation of GPx4 in mice provides a valuable tool for further elucidating the interplay between lipid peroxidation, cell death pathways, and AMD pathogenesis, offering new...

透射电子显微镜(transmission electron microscope，TEM)是检测细胞超微结构的常用工具，目前许多研究用TEM检测RPE细胞超微结构时是将体外培养的RPE细胞消化后观察沉淀的细胞 [6,7,8,9,10] ，但该方法会破坏RPE细胞原本的生长状态，不能真实地反映体外培养RPE细胞的超微 ...

人诱导多能干细胞 （hipsc） 视网膜色素上皮 （rpe）移植是治疗rpe变性（如 年龄相关性黄斑变性 ）的一种有前景的细胞治疗方法。然而，目前的rpe替代疗法面临重大挑战。

rpe 特异性 mfp2 敲除表明 rpe 变性是细胞自主的，但对潜在的神经视网膜有负面影响。 该摘要于 2022 年 5 月 1 日至 4 日在科罗拉多州丹佛市举行的 2022 年 ARVO 年会上以虚拟形式呈现。

Human primary RPE cells were cultured in the presence of A2E (10μM) and/or 3MA (10mM) and subjected to TEM analysis. Note that in the presence of A2E, an autophagic vacuole is visible (arrows)....