2024年12月25日 · RPS14 (Ribosomal Protein S14) is a Protein Coding gene. Diseases associated with RPS14 include Chromosome 5Q Deletion Syndrome and Protein-Deficiency Anemia. Among its related pathways are Peptide chain …

40S ribosomal protein S14 is a protein that in humans is encoded by the RPS14 gene. [5] [6] [7] Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins.

lower RPS14 predicts prolonged survival and possible response to lenalidomide in lower risk MDS patients. RPS14 and RPS19 have distinct roles in regulating the MDM2-p53 feedback loop in response to ribosomal stress; Loss of RPS14 is associated with 5q-syndrome.

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is …

2025年1月4日 · Fine-structure map of the human ribosomal protein gene RPS14. Integrated analyses of translatome and proteome identify the rules of translation selectivity in RPS14-deficient cells.

The RPS14 gene provides instructions for making one of approximately 80 different ribosomal proteins, which are components of cellular structures called ribosomes. Learn about this gene and related health conditions.

2016年2月15日 · In a newly generated conditional-knockout mouse model of Rps14, we found that Rps14 haploinsufficiency is sufficient to cause a p53-dependent erythroid-differentiation defect, associated with...

2024年11月3日 · Title: Genome-wide functional integration identified MAZ-controlled RPS14 dysregulation in hepatocellular carcinoma. RPS14 promotes the development and progression of glioma via p53 signaling pathway.

rps14是40s核糖体亚基的一部分，参与蛋白质的生物合成过程。 其作用机制涉及到与核糖体RNA及其他核糖体蛋白协同作用，促进肽链的延伸，是蛋白质合成关键环节的一部分。

Objectives: Ribosomal protein S14 (RPS14) plays a key role in erythropoiesis and causes p53 activation in 5q- syndrome. However, the oncogenic potential of RPS14 is not understood in leukemia and high-risk myelodysplastic syndrome (MDS).