Ribosomal protein S6 (rpS6 or eS6) is a component of the 40S ribosomal subunit and is therefore involved in translation. Mouse model studies have shown that phosphorylation of eS6 is involved in the regulation of cell size , cell proliferation , and glucose homeostasis .

Dec 25, 2024 · RPS6 (Ribosomal Protein S6) is a Protein Coding gene. Diseases associated with RPS6 include Tuberous Sclerosis and Lymphangioleiomyomatosis. Among its related pathways are Peptide chain elongation and Nervous system development. Gene Ontology (GO) annotations related to this gene include RNA binding and structural constituent of ribosome.

该基因编码一种细胞质核糖体蛋白，它是 40S 亚基的一个组成部分。 该蛋白属于核糖体蛋白的 S6E 家族。 它是核糖体中蛋白激酶的主要底物，具有被不同蛋白激酶磷酸化的五个 C 末端丝氨酸残基的亚群。 磷酸化由多种刺激物诱导，包括生长因子、肿瘤促进剂和促细胞分裂剂。 去磷酸化发生在生长停滞时。 该蛋白质可能有助于通过特定类别的 mRNA 的选择性翻译来控制细胞生长和增殖。 作为典型的编码核糖体蛋白的基因，该基因有多个经过处理的假基因分散在基因组中 …

Dec 21, 2021 · Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been recognized as a surrogate marker for the activated PI3K/AKT/mTORC1 pathway, which occurs in many cancer types.

Feb 11, 2025 · rpS6, especially in its unphosphorylated form, is a selective mediator of TRAIL-induced apoptosis the phosphorylation of Tyr(1077) on LepRb during receptor activation, substantiate the hypothalamic regulation of STAT5 and S6 by leptin, and define the alternate LepRb signaling pathways

Jan 14, 2013 · We show that tissue lacking S6Ks 1 and 2 (S6K1 and S6K2), displays a defect in the ribosome biogenesis (RiBi) transcriptional program after feeding. Over 75% of RiBi factors are controlled by S6K,...

rpS6, especially in its unphosphorylated form, is a selective mediator of TRAIL-induced apoptosis; Structure, localization and molecular assembly in vitro and in vivo of a human rpS6, were examined using antibodies (Abs) prepared by immunizing rabbits with synthetic peptides.

RPS6 (ribosomal protein S6)蛋白是一种垂直生长和生殖发育的调控蛋白，它在生物体内有很多重要的作用。 本文将探讨RPS6蛋白在细胞增殖、蛋白合成、信号传导等方面的作用。 首先，RPS6蛋白在细胞增殖中扮演了重要的角色。 细胞增殖是生物体生长和发育的基础，而RPS6蛋白参与了细胞增殖过程中的多个关键步骤。 研究发现，RPS6蛋白参与了细胞周期的调控，特别是在细胞的S阶段，即DNA复制阶段。 RPS6蛋白的磷酸化状态调节了其与其他细胞周期蛋白的 …

Phosphorylation of Ribosomal Protein S6 (RPS6) was the first post-translational modification of the ribosome to be identified and is a commonly-used readout for mTORC1 activity.

Feb 9, 2025 · Clinical resource with information about RPS6, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.