2024年12月25日 · RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) is a Protein Coding gene. Diseases associated with RRM2 include Diamond-Blackfan Anemia 20 and Choriocarcinoma. Among its related pathways are pyrimidine deoxyribonucleotides biosynthesis from CTP and purine nucleotides de novo biosynthesis.

Ribonucleoside-diphosphate reductase subunit M2, also known as ribonucleotide reductase small subunit, is an enzyme that in humans is encoded by the RRM2 gene. [5][6] This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides.

rrm2被认为是诊断、治疗和预后预测的一个有前途的靶标，对dna复制和癌细胞增殖至关重要。rrm2调控的分子机制极其复杂。例如，rrm2可以受某个途径调节，也可以调节该途径，形成反馈信号。在从转录到翻译的过程中，几乎每一个步骤都会发生调控。

2024年1月1日 · Ribonucleotide reductase M2 (RRM2) is a small subunit in ribonucleotide reductases, which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides, maintaining the dNTP pools for DNA biosynthesis, repair, and replication. RRM2 performs a critical role in the malignant biological behaviors of cancers.

编码蛋白 (M2) 的合成以细胞周期依赖性方式进行调节。 该基因的转录可以从替代启动子开始，这会产生两种 N 末端长度不同的亚型。 已在 1 号和 X 号染色体上鉴定出相关的假基因。 [RefSeq 提供，2009 年 9 月] This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides.

2020年12月7日 · RRM2 exerts an anti-ferroptotic role in liver cancer cells by sustaining GSH synthesis. Serum RRM2 will be useful as a biomarker to evaluate the degree to which ferroptosis is suppressed and improve diagnostic efficiency for liver cancer.

2024年12月30日 · 本文将详细介绍RRM2基因的表达模式及其在发育中的作用，通过RNA测序和芯片技术分析其在不同组织和发育阶段的表达特征，探讨其在胚胎发育、器官形成和细胞分化中的关键角色，并研究其在特定发育阶段的关键调控因子及其功能的实验验证。 了解RRM2基因 RRM2基因，全名ribonucleotide reductase regulatory ...

RRM2 is a new molecular marker for the diagnosis and clinical outcomes of cervical cancer. It is involved in cervical carcinogenesis and predicts poor survival. these findings suggest that RRM2 plays a crucial role in gastric tumorigenesis and may serve as a potential prognostic marker and therapeutic target in gastric cancer.

2025年2月19日 · Circular RNA RRM2 alleviates metabolic dysfunction-associated steatotic liver disease by targeting miR-142-5p to increase NRG1 expression. Identification of RRM2 as a key ferroptosis-related gene in sepsis. Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor.

RRM2 is a crucial subunit of ribonucleotide reductase. In this article, we provided a comprehensive analysis of RRM2 with immune infiltration in pan-cancer. We focused on the hotspots of ferroptosis-related gene RRM2 and immunotherapy.