Standard Method Performance Requirements (SMPRs®) are a unique and novel concept for the analytical methods community. SMPRs are voluntary consensus standards, developed by stakeholders, that prescribe the minimum analytical performance requirements for classes of analytical methods.

The AOAC/IUPAC protocol for interlaboratory studies requires the use of a minimum of 8 laboratories examining at least 5 materials to obtain a reasonable estimate of this variability parameter, which has been shown to be more or less independent of analyte, method, and matrix. By definition sR does not enter into single-laboratory validation.

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AOAC SMPR® 2024.006 Standard Method Performance Requirements (SMPRs®) for Determination of Milk Fat Globule Membrane Proteins in Infant and Adult/Pediatric Nutritional Formula

... improved digestion conditions are compared to the AOAC method 2015.01 23 in Table 3, which shows the RSD obtained for the two methods. These results were obtained for spiked samples to 100...

Background X An OMB Working Group created to consider the question of RSDi recommended the following: The RSDi of a method should not exceed 80% of the reproducibility standard deviation, or in AOAC’s case, no more than 80% the performance requirement specified for the relative standard deviation of reproducibility (RSDR) in the applicable SMPR.

AOAC is very careful to include participants from as many . international standards. Commonly known as the “SMPR Guidelines.” The first version . the analytical requirements of a method. Several early “acceptance . significantly from one another in basic format. AOAC realized that . a guidance document was needed to promote uniformity.

This equation was 1 defined from a practical by Horwitz consideration et al number of collaborative studies done by AOAC For the purposes of this document, examples to 100%. The equation R = (1-0.5logC) 2is: % RSD where R%RSD is the inter-laboratory CV and C is the concentration of analyte in as a decimal fraction

Background X Some method developers have been submitting method validation manuscripts containing data for repeatability (RSDr) that is actually intermediate precision (RSDi). X Traditional RSDr data consists of replicate analysis to a common sample by a single analysis, using a single instrument, over a short duration (a day).

2010年10月15日 · Acceptable RSD values obtained from the Horwitz function and from the AOAC Peer Verified Methods program according to the concentration level of analyte (ppm = parts per millions, ppb = parts per billions).