2019年3月13日 · HP1 is a dynamic epigenetic determinant mainly involved in heterochromatin formation, epigenetic gene silencing and telomere maintenance. Furthermore, recent studies …

2005年6月28日 · Heterochromatin protein 1 (HP1), a component of condensed chromatin, was discovered more than 10 years ago and subsequently found to play important roles in …

2018年10月10日 · Heterochromatin protein 1 γ (HP1γ) is a well-known chromatin protein, which regulates gene silencing during the execution of processes associated with embryogenesis,...

HP1 proteins are fundamental units of heterochromatin packaging that are enriched at the centromeres and telomeres of nearly all eukaryotic chromosomes with the notable exception …

Isoforms of heterochromatin protein 1 (HP1) have been known to perform a multitude of functions ranging from gene silencing, gene activation to cell cycle regulation, and cell differentiation. …

2014年3月12日 · Our results reveal that NDR kinase catalyses the hinge-specific phosphorylation of human HP1α during G2/M in vivo and this orchestrates accurate chromosome alignment …

Non-histone chromatin proteins such as the Heterochromatin Protein 1 (HP1) proteins are critical regulators of transcription, contributing to gene regulation through a variety of molecular …

2022年12月19日 · Hp1α/β deficiency reduces cell proliferation, ribosomal RNA biosynthesis and mobility of Nucleophosmin, a major nucleolar component. Nucleolar integrity and function …

异染色质蛋白 1 (hp1) 是一种非组蛋白染色体蛋白，首先在果蝇中被鉴定为组成型异染色质的主要成分，在包括人类在内的许多物种中稳定表观遗传基因沉默是必需的。

2023年9月12日 · HP1 and H3K9 methylation, as hallmarks of heterochromatin, have a central role in cell lineage and fate determination, yet the underlying mechanisms remain elusive. Lixia et …