Nov 1, 2019 · DNA/protein binding mode of ruthenium (II) complexes is high-lighted. In this review we summarize our work on development of Ru complexes with potential antitumor activity, which was performed over the last few years.

Jun 1, 1990 · What Are the Major Physicochemical Factors in Determining the Preferential Nuclear Uptake of the DNA “Light-Switching” Ru(II)-Polypyridyl Complex in Live Cells via Ion-Pairing with Chlorophenolate Counter-Anions?.

Aug 11, 2021 · This work presents the highest affinity mono-intercalating DNA binding complex to date, and represents the shortest linked Ru II (dppz) complex capable of DNA threading. Given the length of tpphz and the diameter of duplex DNA, any further reduction in the threading linker length could not be accommodated across the DNA helix (Figure 1 ).

Dec 1, 2018 · Ru complexes target various DNA conformations and affect DNA processing enzymes. DNA binding modes of Ru complexes of biological significance are highlighted. Ru complexes and light or ionizing radiation synergistically damage DNA. Ruthenium complexes exhibit a broad variety of biological and biomedical activities including anticancer efficiency.

Oct 18, 2009 · Here, we present a dinuclear ruthenium (II) polypyridyl system that works as a multifunctional biological imaging agent staining the DNA of eukaryotic and prokaryotic cells for both luminescence...

Aug 25, 2016 · Ruthenium (II) polypyridyl complexes can intercalate DNA with high affinity and prevent cell proliferation; however, the direct impact of ruthenium-based intercalation on cellular DNA...

May 14, 2021 · The dinuclear Ru (II) complex was found to display a distinctive blue-shifted ‘light-switch emission on its binding to G-quadruplex DNA compared with the duplex DNA (maxima of ~630 and >650...

Jun 1, 2024 · The photocleavage of plasmid pUC19 DNA was observed upon the irradiation of 1–3 with visible and red light, attributed to the sensitized generation of 1 O 2 by the complexes. These findings indicate that the bim ligand, together with pydppn, serves to shift the absorption of Ru(II) complexes to the photodynamic therapy window, 600–900 nm ...

Sep 15, 2021 · Ru(II)-polypyridyl complexes, binding to DNA, can cause DNA photodamage under irradiation. The AuNP-1-3 cellular uptake and localization can be tracked via confocal fluorescence microscopy. The NPs were localized in the cytoplasm and nuclei of cells [65].

[Ru(bpy)2dppz]2+和[Ru(phen)2dppz]2+作为脱氧核糖核酸(DNA)分子的光开关引起了广泛关注，成为探索DNA螺旋结构的有力工具. 由于钌化合物优异的光物理和光化学性质，它们的相互作用已被深入研究。