High expression of RUNX1 in colorectal cancer subtype …
2024年8月1日 · To explore the transcriptional impact of Runx1 on metabolic pathways in colorectal cancer, we conducted bulk RNA-seq analysis on MC38 cells transfected with shNT …
Nat Immu | 华中科大，北大，郑大团队发现肿瘤导致血小板增多和 …
2023年11月10日 · 活化的ahr结合转录因子runx1基因的启动子，促进runx1转录。 RUNX1随后影响MEP的其他基因表达，使MEP倾向分化为巨核细胞，导致血小板增多、红细胞减少。
Tumor cell-released kynurenine biases MEP differentiation into ...
2023年11月2日 · Here we show that tumor cell-released kynurenine (Kyn) biases megakaryocytic–erythroid progenitor cell (MEP) differentiation into megakaryocytes in …
Here we show that tumor cell-released kynurenine (Kyn) biases megakaryocytic–erythroid progenitor cell (MEP) diferentiation into megakaryocytes in individuals with cancer by …
Mol Can | 表观遗传重编程增强CD8 + T细胞功能，并改善对免疫治 …
该研究证明，地西他滨对Runx3的甲基化重编程在低剂量地西他滨和抗PD-1组合改善治疗反应中起关键作用，并且Runx3的表达水平是抗PD-1治疗反应的潜在生物标志物。 作者团队招募了两 …
RUNX1-induced upregulation of PTGS2 enhances cell growth
2024年5月22日 · Runt-related TF 1 (RUNX1), a member of the core-binding factor family of TFs, is involved in the regulation of a series of cellular processes, including cell growth, …
RUNX1 is a promising prognostic biomarker and related to …
2022年5月9日 · Our findings suggest that RUNX1 expression correlates with patient outcomes and immune infiltrate levels of CAFs in multiple tumors. Additionally, the increased level of …
mc38异种移植模型的免疫学特性使其成为癌症研究的通用工具。 物种：小鼠，C57BL/6品系；雌性 组织：结肠；疾病：结肠腺癌
The Kyn–AhR–RUNX1 pathway regulates MEP differentiation into...
Cyp1a1 and Cyp1b1 expression in MEPs was determined by RT–qPCR (g), and MEPs were stained for RUNX1 (h). i, Ahr–/– mice were inoculated with MC38 cells, tumor-bearing mice …
Epigenetic reprogramming of Runx3 reinforces CD8 + T-cell …
2023年5月16日 · We demonstrate that the DNA methylation of Runx3 plays a critical role in CD8+ T-cell infiltration and differentiation during decitabine-primed PD-1-ab immunotherapy, which …