The Th17, Th1 and dual Th17/Th1 cells are important players in rheumatoid arthritis (RA) disease. To assess their roles, the frequency and impact of these cells were investigated in patients with different disease activity. In 14 new cases and 41 established RA patients in …

Recent work suggests strongly that IL-17, an inflammatory cytokine produced primarily by CD4 + Th17 cells, can play a pivotal role in the pathogenesis of many animal models of arthritis, making it a very attractive target for new therapeutics. One of the best-characterized models of RA is collagen-induced arthritis (CIA).

2023年2月17日 · Th1 cytokine secretion was observed to contribute to the increase of Th17 infiltration and IL-17 production in synovial tissues during RA. 158 Follicular helper T (Tfh) cells, a subset of...

在转化生长因子β (TGF-β)、IFN-γ、IL-2、IL-12 和 IL-21 等炎症细胞因子的刺激下，T 细胞分化为 Th1 和 Th17 细胞，并产生和释放大量炎症因子分子。 T 调节细胞 (Treg) 和 Th2 细胞可以产生抗炎细胞因子，例如 IL-2、IL-4 和 IL-10，但是在 RA 中，这种抗炎反应是不充分的。 Th1 和 Th17 细胞释放额外的炎症分子，并通过 RANKL 和 CD40L 发出信号，触发巨噬细胞和滑膜成纤维细胞的免疫反应。 RANKL 是与 NF-κB 信号转导通路相关的配体，被认为是 RA 中主要的炎症通 …

Here, we show that TNF-α promotes a reduction and expansion in the frequency of both T cell subsets producing IFN-γ and IL-17, respectively. Selective blockade of TNFR1 or TNFR2 on Th1 and Th17 cells revealed that TNFR2 mediates the decrease in IFN-γ production, while signaling through both receptors augments IL-17 production.

2008年7月1日 · Th17: differentiation to the Th17 phenotype requires expression of the transcription factor ROR-γt. Th17 cells exert inflammatory effects and combat extracellular pathogens. The Th17 pathway is prominently involved in inflammation and autoimmunity. Thus, Th17 cells are pivotal in RA [7].

2018年2月1日 · Understanding the mechanisms involved in the regulation of pathogenic Th17 cell activity is instrumental for the identification of Th17 cell-specific targets that are relevant for RA treatment, and can help to improve current RA therapies or lead to the development of novel RA treatment strategies.

2 天之前 · The characteristic Th subpopulations in RA are Th1, Th17, Th22, and Treg, exhibiting considerable flexibility and plasticity in patients and producing significant amounts of inflammatory cytokines (IL-1, IL-6, IL-12, IL-17, and IFNγ), while Treg cells are responsible for controlling the pathological immune response by producing IL-10 and TGF ...

2017年7月21日 · IL-17-secreting helper CD4 T cells (Th17 cells) constitute a newly identified subset of helper CD4 T cells that play a key role in the development of rheumatoid arthritis (RA) in its animal models. Recently, several models of spontaneous RA, which elucidate the mechanism of RA onset, have been discovered.

2025年3月14日 · 1989年Th1和Th2细胞二分法奠定T细胞研究基础，2005年Th17细胞发现改写免疫学。 ... IL-17家族包括六个成员（IL-17A至IL-17F），它们通过IL-17受体（IL-17 Ra至IL-17 Re）介导其生物学功能。 ... 动态可塑性：Th17细胞在慢性炎症中可转化为促炎的Th1样细胞，或分化为调节性Th17 ...