Rab小GTP酶（小G蛋白）是单体GTP结合蛋白，大约含有200个氨基酸。人类基因组编码超过60个Rab。此外，可以通过选择性剪接产生Rab异构体参与各种细胞学过程。

Rabs are GTP-binding proteins with conserved functions in membrane trafficking. They are regulated by a diverse group of structurally unrelated GDP-GTP exchange factors (GEFs), and a family of GTP-hydrolysis activating proteins (GAPs) containing the conserved TBC domain.

2009年7月15日 · Rab GTPases control all aspects of intracellular vesicle trafficking by acting as regulatable switches that recruit effector molecules when in their active GTP-bound form. There are...

2019年8月1日 · Rab GTPases and their regulatory proteins play a crucial role in vesicle-mediated membrane trafficking. During vesicle membrane tethering Rab GTPases are activated by GEFs (guanine nucleotide exchange factors) and then inactivated …

2025年1月8日 · The activation of Rab GTPases is controlled by guanine nucleotide exchange factors (GEF) that catalyze the exchange of bound GDP with GTP and GTPase activating proteins (GAP) that accelerate...

In this review we give an overview of Rab proteins with a focus on the current understanding of their regulation by GEFs, GAPs and GDI.

2009年8月25日 · Rab reactivation is catalyzed by guanine nucleotide exchange factors (GEFs) that speed release of Rab-bound GDP, permitting rebinding of cytosolic GTP. Active GTP-bearing Rabs are stabilized on membrane surfaces by binding to their cognate effector proteins (6).

2014年1月1日 · Each Rab has a cognate GDP–GTP exchange factor (GEF) promoting release of GDP and subsequent binding of GTP, and a GTPase activating protein (GAP) stimulating the slow intrinsic GTP hydrolysis. Together these GEF and GAP regulators determine when and where a specific Rab is activated, and how long its activity will persist.

2019年11月13日 · Intracellular trafficking depends on the function of Rab GTPases, whose activation is regulated by guanine exchange factors (GEFs). The Rab5 GEF, Rabex5, was previously proposed to be auto-inhibited by its C-terminus. Here, we studied full-length Rabex5 and Rabaptin5 proteins as well as domain delet …

Rabs are the largest family of small GTPases and are master regulators of membrane trafficking. Following activation by guanine-nucleotide exchange factors (GEFs), each Rab binds a specific set of effector proteins that mediate the various downstream functions of that Rab.