Rab (Ras-related in brain) proteins form the largest section of the Ras superfamily of small GTPases. The Rab family proteins regulate intracellular membrane trafficking processes including vesicle budding, tethering, and fusion. The isoforms Rab11a, Rab11b, and Rab11c/ Rab25 constitute the Rab11 subfamily based on specific sequence motifs. [7] .

2012年9月1日 · Rab11 is known to associate primarily with perinuclear recycling endosomes and regulate recycling of endocytosed proteins. However, the recycling step in which Rab11 participates remains unknown. We show here that, in addition to causing tubulation of recycling endosomes, Rab11 depletion gives rise …

Rab11, an evolutionary conserved ubiquitous-ly expressed subfamily of the Ypt/Rab gene family, is associated with recycling endosomes (REs) and has been implicated in regulating vesicular trafficking through recycling of endosomal compartment (REC) and early endosomes (EEs) to the trans- Golgi network (TGN) and plasma membrane through recycling ...

Overexpression of Rab11 has been shown to significantly enhance vesicle trafficking. On the other hand, a reduced expression of Rab11 was observed in several neurodegenerative diseases. Current evidence appears to support the notion that Rab11 and its cognate proteins may be potential targets for therapeutic intervention.

Rab11是Rab小分子GTP酶家族的成员.在细胞内膜泡再循环途径中,Rab11作为重要调节因子,介导膜泡从内体向质膜的运输.近年来随着对Rab11研究的深入,人们发现该蛋白质在多种细胞生命活动中发挥着关键作用.现对Rab11的结构,效应蛋白及功能等方面进行了综述.

2019年7月1日 · Rab11a plays a major role in the homeostasis of endosomal maturation. Deficiency of Rab11a results in a perturbation in endosome-TGN recycling of M6PR. The study reveals novel roles for Rab11 in the endosomal/lysosomal pathway.

2024年11月26日 · The Rab11-Rab8 cascade mediated by the Rab8 guanine nucleotide exchange factor (GEF), Rabin8, orchestrates multiple membrane transport processes, but Rab membrane loading and exchange dynamics are unclear. Here, we use advanced fluorescence imaging approaches to characterize Rab11, Rab8, and Rabin8 protein dynamics.

Rab11 is one of the members of Rab protein family, which belongs to small GTPases. As an important regulator on vesicular recycling pathways, Rab11 mainly controls the transport of vesicles from endosomes to plasma membrane.

Rab11-positive vesicles were found to transiently interact with lysosomes, as well as with late endosomes (LEs) at the cell periphery, indicating that this interaction is required for the last steps of LE/lysosome exocytosis.

2024年12月25日 · RAB11B (RAB11B, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB11B include Neurodevelopmental Disorder With Ataxic Gait, Absent Speech, And Decreased Cortical White Matter and Lissencephaly. Among its related pathways are Vesicle-mediated transport and Metabolism of proteins.