2024年6月26日 · Rab1A and Rab1B (Rab1) act by promoting TMED10 oligomerization, thereby enhancing cargo translocation into the ERGIC. In contrast, Rab2A collaborates with KIF5B to …

2024年1月4日 · Activated Rab1A is retained on the ER and induces the oligomerization of ER-shaping protein RTNs and REEPs, eventually triggering an increase of ER complexity. In …

2021年8月10日 · Rab1A, as a highly conserved small guanosine triphosphatase (GTPase), predominantly regulates intracellular vesicular trafficking from the endoplasmic reticulum (ER) …

Activated Rab1A is retained on the ER and induces the oligomerization of ER-shaping protein RTNs and REEPs, eventually triggering an increase of ER complexity. In various models, from …

2024年12月25日 · RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth …

2022年4月20日 · Rab1A and Rab1B are found predominantly at the membrane of endoplasmic reticulum (ER) and Golgi apparatus 41, 46. They have also been detected on lipid rafts 59 and …

该研究发现定位于ERGIC的Rab蛋白—Rab1和Rab2显著调控THU通路，并揭示了其具体作用机制。 Rab GTPases作为细胞内膜泡运输的分子开关，在蛋白分泌中扮演关键角色【5】。 通过 …

Structural analysis demonstrates that Thr75 phosphorylation renders Rab1A in a constantly active state by preventing interaction with GDP-dissociation inhibitor (GDI). Activated Rab1A is …

2020年7月24日 · We found that components of the COPII coat remain associated with the ERES while cargo is extruded into COPII-uncoated, non-ER associated, Rab1 (herein referring to …

We examined the sub-cellular localization of exogenous Rab1A in rat insulinoma INS-1E cells by using confocal microscopy. It has been reported that the Rab1A is mainly localized at the …