2022年10月26日 · LC3-associated endocytosis (LANDO) is a noncanonical function of the autophagy machinery, in which LC3 (microtubule-associated protein light chain) is conjugated to rab5-positive endosomes, using a portion of the canonical autophagy pathway.

Rab5是Ras家族中的一种小GTP酶（24 kDa）。 它从质膜穿梭至早期内涵体并通过与其它蛋白质的相互作用来调节膜泡运输及质膜与早期内涵体的融合。 类似地，Rab7、Rab9和Rab11都是很好的内涵体蛋白标记物。

Rag-mTORC1激活的一个关键分子是液泡H+ATPase (V-ATPase)，它将ATP水解 (外周V1结构域)与通过溶酶体膜的质子转运体 (完整的V0结构域)结合起来，使溶酶体酸化，使其具有降解功能。 当溶酶体管腔内氨基酸水平较低时，V-ATPase抑制Rag GTP酶的活性。

2019年7月25日 · We have identified a novel non-canonical function of several autophagy proteins in the conjugation of LC3 to Rab5 +, clathrin + endosomes containing β-amyloid in a process of LC3-associated endocytosis (LANDO). We found that LANDO in microglia is a critical regulator of immune-mediated aggregate removal and microglial activation in a murine ...

2021年7月2日 · We propose that a form of macropinocytosis coupled to noncanonical autophagy, which we term LC3-associated macropinocytosis (LAM) functions to remove damaged material from the plasma membrane and restore membrane integrity upon injury.

We have identified a novel non-canonical function of several autophagy proteins in the conju-gation of LC3 to Rab5+, clathrin+ endosomes con-taining -amyloid in a process of LC3-associated. endocytosis (LANDO).

2017年1月30日 · Abrogation of Rab5 function and the endosomal pathway results in the accumulation of stressed mitochondria and increases susceptibility to cell death in embryonic fibroblasts and cardiac...

2024年3月1日 · Our study showed that Rab5c upregulates LC3-Ⅱ (microtubule-associated protein 1 light chain 3 beta) protein expression levels by interacting with Beclin1, a key autophagy molecule, which can induce autophagy and promote replication of ADV and RSV.

2020年9月23日 · 小GTP酶 (small GTPase) Rab5/RAB-5定位于早期内吞体，募集效应因子以调控包括内吞循环运输在内的多类型生物学过程[1-3]，例如Rab5效应蛋白Rabenosyn-5与Rab4、膜塑性…

RAB5 also regulates degradation of intracellular components by coordinating the fusion of LC3-decorated autophagosomes with late endosomes to form intermediary compartments before fusion with lysosomes. 35 Furthermore, in an increasing number of cellular processes, RAB5 has been found to regulate autophagy upstream of LC3 conjugation, 36-38 ...