RAB7 is a small GTPase that has the potential of causing malignancy from over 35 tumor types. It is found that RAB7 is an early induced melanoma driver whose levels can define metastatic risk. The RAB7A gene belongs to the RAB family of genes, which is a member of the RAS oncogene family. These genes in the RAB family provides the instructions ...

Rab7 is a late endosome-/lysosome-associated small GTPase, perhaps the only lysosomal Rab protein identified to date. Rab7 plays critical roles in the endocytic processes. Through interaction with its partners (including upstream regulators and downstream effectors), Rab7 participates in multiple regulation mechanisms in endosomal sorting ...

2024年12月25日 · RAB7,Ras oncogene superfamily member,likely involved in vesicular transport of proteins from early to late endosomes and lysosomes,expressed in skeletal muscle RAB7A

2017年10月13日 · We have now used a new approach to analyze the role of Rab7: transient expression of Enhanced Green Fluorescent Protein (EGFP)–tagged Rab7 wt and mutant proteins in HeLa cells. EGFP-Rab7 wt was associated with late endocytic structures, mainly lysosomes, which aggregated and fused in the perinuclear region.

2011年3月1日 · Rab7, the key regulator in endo-lysosomal trafficking investigated extensively in the past decades, is emerging to govern early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome–lysosome transport through different protein–protein interaction cascades.

We have now used a new approach to analyze the role of Rab7: transient expression of Enhanced Green Fluorescent Protein (EGFP)–tagged Rab7 wt and mutant proteins in HeLa cells. EGFP-Rab7 wt was associated with late endocytic structures, mainly lysosomes, which aggregated and fused in the perinuclear region.

现在，我们已经使用一种新方法来分析Rab7的作用：在HeLa细胞中瞬时表达增强型绿色荧光蛋白（EGFP）标记的Rab7 wt和突变蛋白。 EGFP-Rab7 wt与晚期胞吞结构相关，主要是溶酶体，其在核周区域聚集并融合。

Overexpression of wild-type rab7 protein allowed normal transport to late endosomes (mannose 6-phosphate receptor positive), while the rab7N125I mutant caused the VSV G protein to accumulate specifically in early (transferrin receptor positive) endosomes.

Rab蛋白家族是一类Ras相关的GTP结合蛋白,在细胞中发挥确保囊泡转运特异性定位的作用.作为Rab家族的一员,Rab7与其他的Rab成员间既有相似性,又有特异性.其相似性表现在:Rab7与其他的Rab成员有着相似的结构,相似的异戊二烯化过程以及相似的GDP/GTP结合功能;特异性 ...

2009年5月1日 · The small molecular weight G-protein RAB7 is localized to both early and late endosomes and has been shown to be critical for trafficking through the endocytic pathway. The role of RAB7 in the endocytic pathway has been controversial, with some groups reporting that it regulates trafficking from ear …