Rab7-a novel redox target that modulates inflammatory pain
Knockout mice lacking Rab7 in sensory neurons showed normal responses to noxious thermal and mechanical stimuli; however, their pain behavior during inflammatory pain and in response …
Rab7 reduces α-synuclein toxicity in rats and primary neurons
2022年1月1日 · WT Rab7 reduced αSyn-induced ROS production, mitochondrial impairment and DNA damage, confirming the functional relevance of reducing αSyn pathology. We induced …
RAB7 activity is required for the regulation of mitophagy in oocyte ...
2021年7月7日 · In various species, an increase in reactive oxygen species (ROS) caused or was caused by mitochondrial dysfunction, and ATP production failure has been shown to induce …
Refining the Rab7-V1G1 axis to mitigate iron deposition: …
2025年1月1日 · Quercetin ameliorated iron deposition in ALD by regulating the Rab7-V1G1 axis, attenuating ROS elevation, enhancing mitochondrial function, and improving iron utilization, …
Targeting Rab7‐Rilp Mediated Microlipophagy Alleviates Lipid …
2024年6月5日 · Rab7 tyrosine phosphorylation level significantly increased under HGPA treatment, which can be abolished by Rab7 inhibitor CID-1067700 or enhanced by treatment …
RAB7 deficiency impairs pulmonary artery endothelial function …
We found increased medial wall thickness (MWT) and right ventricular systolic pressure (RVSP) and a decreased ratio of PA acceleration time/pulmonary ejection time (PAAT/PET) in RAB7 …
Full article: Reciprocal effects of rab7 deletion in activated and ...
2013年4月15日 · Consistent with the TOMM20 staining results, rab7 −/− T cells had elevated ROS levels relative to wild-type cells, but reduced ROS levels relative to atg5 −/− T cells (Fig. …
RAB7 activity is required for the regulation of mitophagy in oocyte ...
The age-related retardation of female fertility was improved after in vivo treatment of ML098. Thus, RAB7 activity is required to maintain the balance between mitophagy and chromosome …
Reciprocal effects of rab7 deletion in activated and neglected …
2021年7月3日 · This difference may stem from the reduced ROS generation and enhanced survival of rab7(-/-) T cells compared with wild-type and atg5(-/-) T cells in the absence of …
Mitochondria are secreted in extracellular vesicles when lysosomal ...
2023年8月18日 · Deletion of the small GTPase Rab7 in cells or adult mouse heart leads to increased secretion of EVs containing ubiquitinated cargos, including intact mitochondria. The …