Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 …
2018年1月24日 · In summary, we propose that mitochondria–lysosome contacts are regulated in two steps: formation and stabilization of contacts promoted by lysosomal GTP-bound RAB7, …
The PripA-TbcrA complex-centered Rab GAP cascade facilitates
2022年4月4日 · We show that the Rab5-to-Rab7 conversion involves fusion of Rab5-marked early macropinosomes with Rab7-marked late macropinosomes. PripA links the two membrane …
This Is the End: Regulation of Rab7 Nucleotide Binding in …
Accessory proteins regulate the nucleotide binding state of Rab7: guanine nucleotide exchange factors (GEFs) stimulate exchange of bound GDP for GTP, resulting in Rab7 activation, …
Rab regulation by GEFs and GAPs during membrane traffic
2019年8月1日 · Recent evidence shows that in addition to activating and inactivating Rab GTPases, both Rab GEFs and GAPs directly contribute to membrane tethering events during …
Frontiers | This Is the End: Regulation of Rab7 Nucleotide Binding …
2018年10月1日 · This review will discuss the GEF and GAPs that control Rab7 nucleotide binding, and thus regulate Rab7’s activity in endolysosomal trafficking and autophagy. It will …
Rab7: Role of its protein interaction cascades in endo-lysosomal ...
2011年3月1日 · Like other Rab proteins, Rab7 is activated by a set of upstream regulators that converge on its GEF (guanine-nucleotide exchange factor) and GAP (GTPase activation …
RabGTPase激活蛋白结构与功能
<p>RabGTPase激活蛋白 (RabGAPs)是一类含有TBC (Tre2/Bub2/Cdc16)结构域的蛋白家族，在Rab活性调节中起着失活Rab的作用。 近年的研究表明，RabGAPs蛋白通过与特定Rab相互 …
Differential Effects of TBC1D15 and Mammalian Vps39 on Rab7 …
2010年5月28日 · TBC1D15 functioned as a Rab7 GAP in cells, reducing Rab7 binding to its effector protein RILP, fragmenting the lysosome, and conferring resistance to growth factor …
Control of RAB7 activity and localization through the …
2017年11月20日 · Retromer interacts with the RAB 7‐specific GTP ase‐activating protein (GAP) TBC 1D5. Loss of retromer or TBC 1D5 results in depletion of inactive RAB 7 pools and …
TBC-2 Regulates RAB-5/RAB-7-mediated Endosomal Trafficking in
2010年5月12日 · Active Rab5 and Rab7 localize to early and late endosomes, respectively, where they regulate trafficking of cargo from the plasma membrane to the lysosome (Stenmark, …