2022年1月1日 · These findings indicate that Rab7 is able to disrupt the vicious cycle of cellular impairment, αSyn pathology and neurodegeneration present in PD. Stimulation of Rab7 and the autolysosomal degradation pathway could therefore constitute a beneficial strategy for PD.

RAB7A functions as a key regulator in endo-lysosomal trafficking, governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positions, and endosome-lysosome transport …

2025年3月11日 · PD-L1, Na + /K + ATPase and Rab7 levels were detected in endosomes and whole lysates, with β-tubulin as a loading control. r, IP of PD-L1 WT and mutants with HIRP1, CHIP1, Rab11 and Rab7.

2017年7月20日 · Rab7, a member of the Rab GTPase superfamily, has a unique role in the regulation of autophagy. Hypoxic preconditioning (HPC) provides neuroprotection against transient global cerebral ischemia...

2011年3月1日 · Rab7, a small GTPase of the Rab family associated with both the endosome and lysosome, was investigated extensively and well recognized to facilitate endosomal maturation, transport from the late endosome to the lysosome, and positioning of the endosome and lysosome via regulating their movement along cytoskeleton.

Rab7 is a late endosome-/lysosome-associated small GTPase, perhaps the only lysosomal Rab protein identified to date. Rab7 plays critical roles in the endocytic processes. Through interaction with its partners (including upstream regulators and downstream effectors), Rab7 participates in multiple regulation mechanisms in endosomal sorting ...

2022年4月1日 · Rab7 GTP hydrolysis the conversion of Rab7 GTPase from an active GTP-bound to inactive GDP-bound state mediated by GTPase activating proteins (GAPs). Rab7 localizes to lysosomal/late endosomal membranes to regulate their dynamics through its ability to bind Rab7 effector proteins and is mutated in Charcot-Marie-Tooth type 2B.

Indeed, Rab7 GAPs TBC1 domain family member 15 (TBC1D15) and TBC1 domain family member 17 (TBC1D17) regulate Rab7 activity and mediate mitochondrial sequestration in autophagosomes. This study particularly highlighted the role …

2018年11月5日 · As expected, overexpression of HIP1R significantly increased the distribution of PD-L1 to late endosome (RAB7, Fig. 2c) and lysosome (LAMP1, Fig. 2d).

2023年7月5日 · Programmed death-ligand 1 (PD-L1) is a transmembrane ligand for the programmed cell death protein 1 (PD-1), a receptor that inhibits T-cell activity. The PD-L1/PD-1 immune checkpoint axis has been successfully targeted to enhance antitumor immune responses.