Rab8 attenuates Wnt signaling and is required for mesenchymal ...
2021年3月1日 · Immunofluorescent localization and biochemical analyses of Rab8a-deficient, Rab8b-deficient, and Rab8a and Rab8b double-deficient MEFs revealed that Rab8 controls …
The small GTPase Rab8 interacts with VAMP-3 to regulate the …
2015年7月7日 · Here, we have addressed the role of Rab8 (for which there are two isoforms Rab8a and Rab8b), a small GTPase implicated in ciliogenesis, in TCR traffic to the immune …
Rab GTPases in cilium formation and function - PMC
The most extensively studied is intraflagellar transport (IFT), which is a bidirectional motility along the ciliary axoneme that traffics protein cargos such as tubulin subunits and signaling …
Rab8 - SpringerLink
2018年1月1日 · One important question in the field of ciliary trafficking is how the intraflagellar transport (IFT) system, which transports non-membranous particles to and within the primary …
Rab8 GTPase as a regulator of cell shape - Peränen - 2011 ...
2011年8月17日 · Rab8 regulates a membrane recycling pathway that is linked to Arf6, EHD1, Myo5, and Rab11. A hypothesis is presented on the role of Rab8 in the formation of new cell …
Rab11-Rab8 cascade dynamics in primary cilia and membrane …
2024年11月26日 · The Rab11-Rab8 cascade mediated by the Rab8 guanine nucleotide exchange factor (GEF), Rabin8, orchestrates multiple membrane transport processes, but Rab …
Biochemical and structural insights into the auto-inhibited state of ...
2024年11月15日 · Biochemical experiments show that Rab8 first binds to the high-affinity C-terminal site, facilitating subsequent second Rab8 binding to the low-affinity N-terminal site. …
elipsa is an early determinant of ciliogenesis that links the IFT ...
2008年3月23日 · Elipsa binds to Rabaptin5, which, in turn, binds to Rab8, a membrane-associated small GTPase, thus potentially providing a bridging mechanism between IFT …
The small GTPase Rab8 interacts with VAMP-3 to regulate the ... - PubMed
2015年7月15日 · IFT20, a component of the intraflagellar transport (IFT) system that controls ciliogenesis, regulates immune synapse assembly in the non-ciliated T-cell by promoting T-cell …
The roles of evolutionarily conserved functional modules in cilia ...
2013年12月2日 · The Rabaptin5–Rab8–IFT functional coupling may help IFT particle assembly at the site of ciliogenesis, facilitating the transition between vesicular and intraciliary trafficking .