2000年1月1日 · Our model depicts a Rac1-dependent pathway generated by the ligation of β1 integrins on human NK cells leading to p38 MAPK activation that controls the production of the proinflammatory chemokine IL-8. β1 integrin ligation induces tyrosine phosphorylation of the protooncogene p95 Vav, which may catalyze Rac1 activation.

2003年7月1日 · The ERK-MAPK pathway controls Fra-1 expression transcriptionally and posttranscriptionally in colon carcinoma cells containing KRAS oncogenes (E.V. and C.J.M., unpublished results). An important role for Fra-1 in Ras-induced tumorigenesis is suggested by the fact that antisense-mediated inhibition of Fra-1 antagonizes the Ras-induced colony ...

Ras相关C3肉毒素底物1（Rac1）是G蛋白Ras超家族Rho亚家族的一类小分子GTP蛋白酶，参与细胞迁移、肌动蛋白重组、肿瘤侵袭转移、转录因子调节及血管内皮生成等过程，尤其对细胞骨架构成、伪足形成和方向性运动具有中心调节作用 [2,3] 。

Using pharmacological inhibitors of Rac1-Nox2 enzyme complex, we reported the involvement of this holoenzyme and associated oxidative stress in the activation of p38MAPK. These findings suggest the role of Rac1-Nox2-derived oxidative stress in the activation of apoptotic MAPK pathways in the β-cell under glucolipotoxic conditions .

2021年11月22日 · In the present study, we found that the recovery of NIS expression induced through MAPK pathway inhibition can be enhanced by potentiating RAC1 activity in thyroid cell systems. The negative impact on NIS expression induced by the MAPK-activating alterations, NRAS Q61R and BRAF V600E, was partially reversed by the presence of the MEK 1/2 ...

2009年1月22日 · Mitogen-activated protein kinases (MAPK), p38, and extracellular stimuli-responsive kinase (ERK), are acutely but transiently activated in platelets by platelet agonists, and the agonist-induced platelet MAPK activation is inhibited by ligand binding to the integrin alpha(IIb)beta(3). Here we show t …

We describe two signaling events downstream of ERK-MAP kinase contributing to cell motility in colon carcinoma cells. The Fos family member Fra-1 is expressed in an ERK-dependent manner. Silencing of Fra-1 expression with short interfering RNAs leads to losses of cell polarization, motility, and invasiveness in vitro.

The MAP kinase (MAPK) p38 plays a key role in regulating inflammatory responses. Here, we demonstrate that beta1 integrin ligation on human NK cells results in the activation of the p38 MAPK signaling pathway, which is required for integrin-triggered IL-8 production. In addition, we identified some …

2023年8月8日 · Rac1（Ras-related C3 botulinum toxin substrate 1）是Rho GTPase家族的一员，是细胞内重要的信号传导分子。 Rac1信号通路参与了多种细胞功能和生理过程，包括细胞形态改变、细胞迁移、细胞增殖和细胞黏附等。 Rac1信号通路的主要内容如下： 激活：Rac1在空间上被定位于细胞膜上，并以非活性的GDP结合状态存在。 当受到外界刺激，如成长因子、细胞外基质和细胞间相互作用等，Rac1会受到特定的Guanyl nucleotide Exchange Factor（GEF）的激 …

2000年1月1日 · Our model depicts a Rac1-dependent pathway generated by the ligation of β1 integrins on human NK cells leading to p38 MAPK activation that controls the production of the proinflammatory chemokine IL-8. β1 integrin ligation induces tyrosine phosphorylation of the protooncogene p95 Vav, which may catalyze Rac1 activation.