2006年3月3日 · This review focuses on the role of the Rac1 and Rac2 GTPases in the activation of the various NOX family members. The role for reactive oxygen species (ROS) in cellular …

2024年2月14日 · Here we reveal the cryo-EM structure of the human NOX2–p22 complex activated by essential fragments of p47, p67 and Rac1, at a resolution of 2.79 Å. This structure …

2022年10月14日 · Here, we present the structure of the human NOX2 core complex bound to a selective anti-NOX2 antibody fragment. The core complex reveals an intricate extracellular …

总的来讲，该研究揭示了三个主要胞浆因子p47、p67及Rac1片段如何协同作用并激活NOX2的过程。 p67与Rac1形成的复合体紧贴着NOX2的脱氢酶结构域，诱导其收缩，这稳定了NADPH结 …

2021年7月8日 · Activated Rac1, via Nox2-ROS, contributes to mitochondrial damage and the development of retinopathy 3, 11. Diabetes also transcriptionally activates Rac1, and its gene …

2024年2月19日 · 作者们发现胞浆组分p67、Rac1和p47如何与NOX2结合并引起构象变化，从而稳定NADPH的结合并将其电子经由FAD、近胞内侧血红素、F215和近胞外侧血红素 ...

Binding of Rac1 GTPase to p67 phox plays a critical role in NOX2 activation by facilitating the assembly of the NOX2 enzyme complex. We tested the hypothesis that Phox-I, a rationally …

Rac1 regulation of NOX2 is important for ROS generation. Small molecule inhibitor of the Rac1-p67 phox interaction prevents platelet activation. Pharmacologic targeting of Rac1-NOX2 axis …

2018年2月20日 · Rac1 GEFs drive physiological and pathological events related to both NOX-mediated ROS and actin cytoskeleton regulation. Rac1 levels may control cell migration and …

2010年1月22日 · Using cell-attached patch-clamp analysis and compounds that alter Rac1 activity, we show acute regulation of ENaC via Rac1-mediated NOX2 signaling in type 1 and 2 …