2024年12月25日 · RAC2 (Rac Family Small GTPase 2) is a Protein Coding gene. Diseases associated with RAC2 include Immunodeficiency 73A With Defective Neutrophil Chemotaxis And Leukocytosis and Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia. Among its related pathways are Constitutive Signaling by Aberrant PI3K in Cancer and GPCR Pathway.

Rac2 (Ras-related C3 botulinum toxin substrate 2) is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. [5] It is encoded by the gene RAC2 .

Rac2 is a 21 kDa small GTPase, a member of the Ras super-family and Rho sub-family of GTPases, that upon activation by a guanine nucleotide exchange factor (GEF), is essential in regulating immunological processes and actin cytoskeletal re-arrangement in neutrophils and other immune system cells and is especially important for inflammatory ...

A gain-of-function RAC2 mutation is associated with bone-marrow hypoplasia and an autosomal dominant form of severe combined immunodeficiency. The Rac2 GTPase contributes to cathepsin H-mediated protection against cytokine-induced apoptosis in insulin-secreting cells.

2024年2月19日 · Rho GTPases 是一类重要的细胞信号传导蛋白，在细胞内起着关键的调控作用。 它们是小的 GTP酶，属于 Ras超家族，包括RhoA、RhoB、RhoC、Rac1、Rac2、Cdc42等多种成员。 Rho GTPases通过调节细胞骨架重塑、细胞迁移、细胞黏附、细胞极化和基因转录等过程参与细胞生物学的多个方面。 在这篇综述中，作者提出并讨论了Rho GTPases的自组织能力，即直接从低阶状态过渡到高阶状态。 也讨论Rho GTPase的自组织模式形成对细胞功能的优势。 …

Rac2 mRNA was expressed in the bone marrow of WT recipients of Rac2−/− stem cells and in human mesenchymal stem cells. The data presented here suggest that Rac2 in hematopoietic cells regulates leukocyte lineage distribution and Rac2 in nonhematopoietic cells might contribute to regulating circulating neutrophil counts.

While the genetic absence of Rac2 did not affect osteoclast survival, Rac2 −/− osteoclasts showed reduced basal resorptive activity and a clear defect in the ability to respond to the chemoattractant CSF1. The finding of increased expression of Rac1 protein in the genetic absence of Rac2 was surprising and unexpected.

2025年2月9日 · Title: A gain-of-function RAC2 mutation is associated with bone-marrow hypoplasia and an autosomal dominant form of severe combined immunodeficiency. The Rac2 GTPase contributes to cathepsin H-mediated protection against cytokine-induced apoptosis in insulin-secreting cells.

2024年4月11日 · Mutations in the small Rho-family guanosine triphosphate hydrolase RAC2, critical for actin cytoskeleton remodeling and intracellular signal transduction, are associated with neonatal severe combined immunodeficiency (SCID), infantile neutrophilic disorder resembling leukocyte adhesion deficiency (LAD), and later-onset combined immune ...

该基因编码小鸟苷三磷酸 (GTP) 代谢蛋白 Ras 超家族的成员。 编码的蛋白质定位于质膜，在那里它调节多种过程，例如分泌、吞噬作用和细胞极化。 这种蛋白质的活性也参与活性氧的产生。 该基因的突变与中性粒细胞免疫缺陷综合征有关。 该基因在 6 号染色体上有一个假基因。 [RefSeq 提供，2013 年 7 月] This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins.