2024年12月25日 · RAD50 (RAD50 Double Strand Break Repair Protein) is a Protein Coding gene. Diseases associated with RAD50 include Nijmegen Breakage Syndrome-Like Disorder and Hereditary Breast Ovarian Cancer Syndrome .

DNA repair protein RAD50, also known as RAD50, is a protein that in humans is encoded by the RAD50 gene. [5] The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1 (also known as Xrs2 in yeast).

2025年3月4日 · The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends.

同源重组修复是精确的修复DSB的方式,MRE11-RAD50-NBS1 (MRN)复合物是参与同源重组修复的关键蛋白,在不同物种之间存在保守性。 从前关于MRN复合物的功能研究主要来源于酿酒酵母和线虫等低等生物,近些年来对哺乳动物MRN复合物的研究提示MRN复合物在高等动物DNA损伤修复中存在功能。 本文综述了MRN复合物的组成和结构及其在DNA损伤同源重组修复中的功能,同时也介绍了MRN复合物异常所带来的人类疾病共济失调性毛细血管扩张综合征类似病症、奈梅亨断 …

2022年5月2日 · Combining pathway reconstitution in electron microscopy, biochemical assays and genetic studies, we show that S. cerevisiae Mre11-Rad50 with or without Xrs2 forms higher-order assemblies in...

RAD50 双链断裂修复蛋白： 该基因编码的蛋白质与酿酒酵母 Rad50 高度相似，后者是一种参与 DNA 双链断裂修复的蛋白质。 该蛋白质与 MRE11 和 NBS1 形成复合物。

RAD50 Mutation is an inclusion criterion in 19 clinical trials for breast carcinoma, of which 15 are open and 4 are closed. Of the trials that contain RAD50 Mutation and breast carcinoma as inclusion criteria, 5 are phase 1 (4 open), 2 are phase 1/phase 2 (1 open), 10 are phase 2 (8 open), and 2 are phase 3 (2 open) [

这个基因编码的蛋白质与酿酒酵母Rad50蛋白质高度相似，Rad50蛋白质参与DNA双链断裂修复。 这个蛋白质与MRE11和NBS1形成复合物，结合到DNA上，并展示许多非同源DNA末端连接所需的酶活性。

RAD50 is a subunit of the MRE11/RAD50/NBS1 (MRN) complex. The MRN complex is recruited to the site of DNA double-strand breaks (DSBs) as part of the DNA damage response (DDR) and plays a pivotal role in the repair of damage via either the homologous recombination (HR) or non-homologous end-joining (NHEJ) pathways.

2000年6月23日 · Rad50cd displays ATPase activity plus ATP-controlled dimerization and DNA binding activities. Rad50cd crystal structures identify probable protein and DNA interfaces and reveal an ABC-ATPase fold, linking Rad50 molecular mechanisms to ABC transporters, including P glycoprotein and cystic fibrosis transmembrane conductance regulator.