RAD52 homolog (S. cerevisiae), also known as RAD52, is a protein which in humans is encoded by the RAD52 gene. [5][6] The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination.

2024年4月24日 · RAD52 is important for the repair of DNA double-stranded breaks 1, 2, mitotic DNA synthesis 3, 4, 5 and alternative telomere length maintenance 6, 7. Central to these functions, RAD52 promotes...

2024年12月25日 · The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands.

2018年10月26日 · Rad52 is among the most important proteins for genome maintenance in yeast, but it seemed mysteriously inconsequential for DNA repair in higher eukaryotes. However, this viewpoint is...

At DNA double-strand breaks, RAD52 was demonstrated to spur alternative pathways to compensate for the loss of homologous recombination functions. At collapsed replication forks, RAD52 activates break-induced replication. In the M phase, RAD52 promotes the finalization of DNA replication.

RAD52 is a DNA/RNA-binding protein that plays a multifaceted role in many intracellular pathways related to DNA repair and the maintenance of genomic stability [1, 2]. Until recently, RAD52 was not thought to be a potential pharmacological target but rather an auxiliary protein that was non-essential in living cells [3, 4].

复蛋白RAD52是体内参与同源重组DNA修复的关键因子。RAD52的表达水平异常与非小细胞肺癌、胃癌、鼻咽 癌、乳腺癌等肿瘤的发生、发展相关。本文对DNA修复蛋白RAD52在肿瘤研究中的应用这一热点问题进行综述。

2023年1月23日 · Rad52 is a highly conserved eukaryotic protein that can mediate the annealing of complementary DNA strands to initiate homologous recombination for the repair of double-strand breaks1.

2017年7月6日 · In this issue of Molecular Cell, Mazina et al. (2017) describe how the Rad52 protein mediates RNA-dependent DNA double-strand break repair via inverse strand exchange. This finding sheds light on how eukaryotes utilize RNA to repair chromosome breaks.

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands.