2024年12月25日 · RAD54L (RAD54 Like) is a Protein Coding gene. Diseases associated with RAD54L include Lymphoma, Non-Hodgkin, Familial and Breast Ductal Carcinoma. Among its related pathways are DNA Damage and Integrated breast cancer pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity.

DNA repair and recombination protein RAD54-like is a protein that in humans is encoded by the RAD54L gene. [5] [6] The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This ...

2024年11月14日 · Title: Overexpression of RAD54L attenuates osteoarthritis by suppressing the HIF-1α/VEGF signaling pathway: Bioinformatics analysis and experimental validation. DNA repair/recombination protein 54L promotes the progression of lung adenocarcinoma by activating mTORC1 pathway.

The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks.

RAD54L exhibits robust expression in both pan-cancer and HCC, exerting a significant influence on the proliferation and migration of HCC cells. These findings highlight its potential as a promising biomarker for pan-cancer and a prospective target for immunotherapy. Keywords: RAD54L, pan-cancer, tumor microenvironment, malignant behavior ...

2023年9月11日 · RAD54L 显示与各种免疫细胞的浸润水平密切相关，包括癌症相关成纤维细胞 (CAF)、内皮细胞和骨髓源性抑制细胞 (MDSC)。 此外，还观察到 RAD54L 与肿瘤突变负荷 (TMB)、微卫星不稳定性 (MSI)、多个免疫检查点和免疫细胞浸润等关键因素之间的关联。 此外，HCC 中 RAD54L 的表达水平与临床病理特征以及免疫细胞浸润之间存在密切关系。 采用 qRT-PCR、蛋白质印迹、集落形成、细胞计数试剂盒-8 (CCK-8)、伤口愈合和 Transwell 检测等实 …

DNA repair/recombination protein 54L promotes the progression of lung adenocarcinoma by activating mTORC1 pathway. Rad54L promotes bladder cancer progression by regulating cell cycle and cell senescence.

目的 探讨DNA修复重组RAD54样蛋白（RAD54-like protein，RAD54L）在口腔鳞状细胞癌（oral squamous cell carcinoma，OSCC）中的表达及功能作用。 方法 利用癌症基因组图谱（The Cancer Genome Atlas，TCGA）数据库中OSCC相关数据，通过Mann-Whitney U检验分析RAD54L在OSCC与对照样本中的表达差异，并采用受试者工作特征曲线评估RAD54L在OSCC诊断中的潜在价值。 通过卡方检验分析RAD54L mRNA表达水平与OSCC患者临床病理数据之间的 …

RAD54L Mutation is a predictive biomarker for use of olaparib in patients. Of the therapies with RAD54L Mutation as a predictive biomarker, 1 is FDA-approved and 1 has NCCN guidelines in at least one clinical setting.

2006年9月8日 · HGNC Approved Gene Symbol: RAD54L. Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38) : 1:46,247,688-46,278,473 (from NCBI) Repair of double-stranded DNA breaks is essential for homologous recombination in somatic cells to protect DNA from damage by ionizing radiation and other genotoxins.