2024年12月25日 · RAF1 (Raf-1 Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with RAF1 include Leopard Syndrome 2 and Noonan Syndrome 5. …

The RAF1 gene mutations change single protein building blocks (amino acids) in the RAF1 protein. These changes increase protein activity and disrupt the regulation of the RAS/MAPK …

2025年2月20日 · Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor. Edin ML, et al. …

2023年4月5日 · In this study, we demonstrate that RAF1, but not its kinase activity, plays a crucial role in the proliferation of both MSI and MSS CRC cell line-derived spheroids and patient …

Raf-1 proto-oncogene, serine/threonine kinase (RAF1, also known as CRAF) is a gene that encodes a protein that functions downstream of RAS and activates MEK1 and MEK2. Fusions, …

The RAF1 gene provides instructions for making a protein that is part of a signaling pathway called the RAS/MAPK pathway, which transmits chemical signals from outside the cell to the …

RAF1; Raf-1 proto-oncogene, serine/threonine kinase. Aliases: NS5, CRAF, Raf-1, c-Raf, CMD1NN. Location: 3p25.2. Summary: This gene is the cellular homolog of viral raf gene (v …

2025年2月9日 · Raf-1 oncogenic signaling is linked to activation of mesenchymal to epithelial transition pathway in metastatic breast cancer cells. Two cases of LEOPARD syndrome- …

Raf1 is a member of the Raf kinase family and regulates many fundamental cell processes, including proliferation, differentiation, apoptosis, motility, and metabolism. However, the …

2025年3月4日 · Serine–threonine kinases of the RAF family, namely ARAF, BRAF and CRAF (also called RAF1; Fig. 1a), are critical signaling mediators from receptor tyrosine kinases …