Dec 25, 2024 · RAF1 (Raf-1 Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with RAF1 include Leopard Syndrome 2 and Noonan Syndrome 5. Among its related pathways are Prolactin Signaling and IL-9 Signaling Pathways.

The RAF1 gene mutations change single protein building blocks (amino acids) in the RAF1 protein. These changes increase protein activity and disrupt the regulation of the RAS/MAPK signaling pathway causing problems with cell division, apoptosis, cell …

Feb 20, 2025 · Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor. Edin ML, et al. Mol Cell Biol, 2005 Jun. PMID 15899852, Free PMC Article.

Apr 5, 2023 · In this study, we demonstrate that RAF1, but not its kinase activity, plays a crucial role in the proliferation of both MSI and MSS CRC cell line-derived spheroids and patient-derived organoids,...

Raf-1 proto-oncogene, serine/threonine kinase (RAF1, also known as CRAF) is a gene that encodes a protein that functions downstream of RAS and activates MEK1 and MEK2. Fusions, rearrangements, missense mutations, nonsense mutations, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

The RAF1 gene provides instructions for making a protein that is part of a signaling pathway called the RAS/MAPK pathway, which transmits chemical signals from outside the cell to the cell's nucleus.

RAF1; Raf-1 proto-oncogene, serine/threonine kinase. Aliases: NS5, CRAF, Raf-1, c-Raf, CMD1NN. Location: 3p25.2. Summary: This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly.

Feb 9, 2025 · Raf-1 oncogenic signaling is linked to activation of mesenchymal to epithelial transition pathway in metastatic breast cancer cells. Two cases of LEOPARD syndrome--RAF1 mutations firstly described in children.

Raf1 is a member of the Raf kinase family and regulates many fundamental cell processes, including proliferation, differentiation, apoptosis, motility, and metabolism. However, the functions of Raf1 have not been completely elucidated. To better understand Raf1 function, we investigated the proteins that interacted with Raf1.

Mar 4, 2025 · Serine–threonine kinases of the RAF family, namely ARAF, BRAF and CRAF (also called RAF1; Fig. 1a), are critical signaling mediators from receptor tyrosine kinases (RTKs) to the downstream ...