2024年12月25日 · RANBP2 (RAN Binding Protein 2) is a Protein Coding gene. Diseases associated with RANBP2 include Familial Acute Necrotizing Encephalopathy and Autosomal …

The RanBP2 gene encodes a very large RAN-binding protein that localizes to cytoplasmic filaments emanating from the nuclear pore complex. RanBP2/Nup358 is a giant scaffold and …

The RANBP2 gene provides instructions for making a protein that typically associates with a protein complex known as the nuclear pore. Learn about this gene and related health conditions.

2016年5月10日 · Here, we show that the RanBP2/RanGAP1*SUMO1/Ubc9 complex functions as an autonomous disassembly machine with a preference for the export receptor Crm1.

Missense mutations in RAN Binding Protein 2 (RANBP2) can cause genetic (also known as familial) acute necrotizing encephalopathy (ANE1). Persons with RANBP2 mutations are …

2024年12月23日 · This study investigated RANBP2 mutations in children with acute necrotizing encephalopathy (ANE) and conducted a systematic review of the differences in clinical …

RAN is a small GTP-binding protein of the Ras superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with …

2021年2月28日 · 该研究首次阐明了RanBP2可利用其SUMO E3连接酶活性调控miRNA沉默途径，最终实现RanBP2对IL-6和TNF-α等促炎性细胞因子的mRNA的翻译抑制，为揭示ANE1的发 …

RANBP2 is the first native and positive allosteric activator known to jump-start and boost directly the activity of KIF5B. The nuclear pore component Nup358 promotes transportin-dependent …

2024年11月26日 · Depletion of the nuclear transport factor RANBP2 by RNAi blocks HIV-1 nuclear import and integration efficiency as assayed by the appearance of circular viral DNAs, …