RANKL biology: bone metabolism, the immune system, and beyond
RANKL was first discovered as a T cell-derived activator of dendritic cells (DCs) and has many functions in the immune system, including organogenesis, cellular development. The essentiality of RANKL in the bone and the immune systems lies at the root of the field of “osteoimmunology.”
RANKL Biology - PMC
RANKL regulates osteolytic bone metastasis through the stimulation of cancer cell migration toward the bone. RANKL acts directly on RANK-expressing tumor cells and promotes cell migration. Tumor cells induce RANKL expression on bone marrow stromal cells, leading to osteoclastic bone resorption.
RANKL - an overview | ScienceDirect Topics
RANKL is a transmembrane molecule expressed by mesenchymal cell and lymphocytes. The soluble form of RANKL is a consequence of proteolytic cleavage. RANKL binds to RANK on hematopoietic cells and activates cytoplasmic adaptor proteins (e.g., tumor necrosis factor receptor-associated factor 6, TRAF6).
Biology of RANK, RANKL, and osteoprotegerin - PMC
RANKL is a type II homotrimeric transmembrane protein that is expressed as a membrane-bound and a secreted protein, which is derived from the membrane form as a result of either proteolytic cleavage or alternative splicing .
RANKL-RANK signaling regulates osteoblast differentiation and …
2018年11月27日 · RANKL signaling drives osteoclastogenesis. In BMSCs, RANKL binding to RANK activates RANKL forward signaling, which inhibits osteoblast differentiation.
ROLE OF RANKL SIGNALING IN BONE HOMEOSTASIS
2024年9月10日 · RANKL and its cognate receptor RANK are crucial regulators of bone metabolism in physiological as well as in pathological conditions. Here we go through the works that unveiled the paramount role of this signaling pathway.
RANKL biology: bone metabolism, the immune system, and beyond
2020年2月7日 · RANKL was first discovered as a T cell-derived activator of dendritic cells (DCs) and has many functions in the immune system, including organogenesis, cellular development. The essentiality of RANKL in the bone and the immune systems lies at the root of the field of "osteoimmunology."
RANKL reverse signalling and bone - Nature Reviews Rheumatology
2018年9月27日 · New research by Hiroshi Suzuki and colleagues shows that reverse signalling of receptor activator of nuclear factor-κB (RANK; also known as TNFRSF11A) ligand (RANKL; also known as TNFSF11) in ...
RANKL - an overview | ScienceDirect Topics
Enhanced RANKL expression plays an important role in bone destruction in patients with myeloma. RANKL is either produced directly by tumour cells or its production (by stromal bone cells or T-lymphocytes) is induced indirectly by tumour cells through secretion of PTH-rP and other cytokines.
The RANK–RANKL–OPG System: A Multifaceted Regulator of …
The RANK–RANKL–OPG system is a complex signaling pathway that plays a critical role in bone metabolism, mammary epithelial cell development, immune function, and cancer. RANKL is a ligand that binds to RANK, a receptor expressed on osteoclasts, dendritic cells, T …
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