Retinoic acid receptor gamma (RAR-γ), also known as NR1B3 (nuclear receptor subfamily 1, group B, member 3) is a nuclear receptor encoded by the RARG gene. [5] [6] Adapalene selectively targets retinoic acid receptor beta and retinoic acid receptor gamma [7] and its agonism of the gamma subtype is largely responsible for adapalene's observed ...

There are three retinoic acid receptors (RAR), RAR-alpha, RAR-beta, and RAR-gamma, encoded by the RARA, RARB, RARG genes, respectively. Within each RAR subtype there are various isoforms differing in their N-terminal region A. [1] Multiple splice variants have been identified in human RARs: four for RARA, five for RARB, and two for RARG. [4]

2024年12月25日 · Retinoic acid receptors (RARs) are nuclear hormone receptors of the NR1B class, which function as heterodimers with retinoid X receptors (RXRs). There are three distinct RAR subtypes: RARalpha, present in most tissue types; and RARbeta and RARgamma, with more selective expression.

The retinoic acid receptors (RAR) belong to the large family of ligand responsive gene regulatory proteins that includes receptors for steroid and thyroid hormones. These proteins contain two highly conserved domains, involved in determining their DNA and ligand binding activities.

2017年3月23日 · We recently demonstrated that retinoic acid receptor-γ (RARγ) is overexpressed and acts as a tumor promoter in hepatocellular carcinoma (HCC). The oncogenic activity of RARγ is...

2010年2月7日 · Retinoic Acid Receptor Gamma (RAR-γ) is one of the isoforms of the retinoic acid receptor targeted by SIRT1, which plays a role in reducing the pathogenesis of Alzheimer's disease by increasing the transcription of α-secretase and reducing the production of toxic Aβ. You might find these chapters and articles relevant to this topic. Feng Zhang, ...

2025年2月8日 · Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes.

2023年3月24日 · RARγ is a therapeutic target for many skin diseases and has potential in cancer treatment. In the current study, we put forward a comprehensive structure–activity relationship study of third and fourth generations of RARγ agonists, addressing multiple crystal structures of RARγ complexes and approved drugs.

the cytoplasmic retinoic acid receptor gamma (RARgamma) controls receptor-interacting protein kinase 1 (RIP1)-initiated cell death when cellular inhibitor of apoptosis (cIAP) activity is blocked. Results show that RARgamma expression is significantly upregulated in human hepatocellular carcinoma (HCC) tissues and demonstrate that RARgamma could ...

视黄酸受体γ： 该基因编码属于核激素受体家族的视黄酸受体。视黄酸受体 (rar) 充当配体依赖性转录调节因子。当与配体结合时，rar 通过以异二聚体形式结合靶基因启动子区域中的视黄酸反应元件 (rare) 来激活转录。在未结合的形式下，rar 会抑制其靶基因的转录。