rar 用作配体依赖性转录调节因子，与类视黄酸 x 受体 (rxr) 异二聚化，后者也包括三种类型，α nr2b1、β (nr2b2) 和 γ (nr2b3)。 RAR 在多种生物过程中发挥关键作用，包括发育、生殖、免疫、器官形成和体内平衡，如在小鼠中进行的维生素 A 缺乏症 (VAD)、药理学和遗传 ...

Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as heterodimers with retinoid X receptors (RXRs) to regulate cell growth, differentiation, survival and death.

Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as heterodimers with retinoid X receptors (RXRs) to regulate cell...

Similar to peroxisome proliferator-activated receptors (PPAR), vitamin D receptor (VDR), thyroid hormone receptor (TR), farnesoid X receptor (FXR) and liver X receptors (LXR), the RAR forms RAR/RXR heterodimers and binds to retinoic acid-responsive elements (RARE) in the regulatory sequences of genes.

3 天之前 · In most cases, RXR binds to the upstream half-site and RAR binds to the downstream, except DR1 and DR0 complexes, whose polarity are reversed. 52-54 The DR5 element, which contains a 5 base pair spacer, is one of the most well-characterised RAREs of the RAR/RXR heterodimer and participates in the activation of gene transcription (PDB ID: 6XWG ...

Our analysis reveals a model of RXR-RAR heterodimer action in which each subunit retains its intrinsic properties in terms of ligand and co-regulator binding. However, their interplay upon the combined action of RAR- and RXR-ligands allows for the fine tuning of heterodimer activity.

视黄酸受体（retinoic acid receptor, RAR）是一类特异性结合视黄酸（retinoic acid, RA）的核受体。 视黄酸是维生素A的代谢产物，参与调控胚胎发育、细胞分化和生长等多种生理过程。

Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are members of the nuclear receptor superfamily whose effects on cell growth and survival can be modulated...

2019年11月5日 · Using biochemical, crystallographic, and cellular approaches, we have set out to explore the spectrum of possibilities to regulate RXR-RAR heterodimer-dependent transcription through various pharmacological classes of RAR- and RXR- specific ligands, alone or …

2 天之前 · Furthermore, we note that the pattern of asymmetric coactivator binding to one monomer of the RXR heterodimer was also observed in RAR-RXR, VDR-RXR, PPARγ-RXRα, and TR-RXRα 49,50, and even ...