经典且复杂的细胞信号通路：RAS/RAF/MEK/ERK - 知乎
RAS蛋白家族包括四种：KRAS (两种剪切体4a和4b)、HRAS、NRAS；四种蛋白序列相似度很高，在细胞膜内的定位略有差异，但都和癌症发生相关。 其中KRAS激活突变突变最常见，其突 …
MAPK/ERK pathway - Wikipedia
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in …
Targeting the RAS/RAF/MAPK pathway for cancer therapy: from
2023年12月18日 · In this review, we delve deeper into the mechanistic insights surrounding RAF kinase signaling in tumorigenesis and RAFi-resistance. Furthermore, we explore and discuss …
The Ras/Raf/MAPK Pathway - Journal of Thoracic Oncology
The Ras/Raf/MAPK pathway is probably the best characterized signal transduction pathway in cell biology. The function of this pathway is to transduce signals from the extracellular milieu to the …
Signaling from RAS to RAF: The Molecules and Their Mechanisms
Over the past few years, structural and biochemical studies have provided new understanding of RAF autoregulation, RAF activation by RAS and the SHOC2 phosphatase complex, and RAF …
KRAS interaction with RAF1 RAS-binding domain and cysteine
2021年2月19日 · Combining our structures and published data, we provide a model of RAS-RAF complexation at the membrane, and molecular insights into RAS-RAF interaction during the …
Signaling from RAS to RAF: The Molecules and Their Mechanisms
RAF family protein kinases are a key node in the RAS/RAF/MAP kinase pathway, the signaling cascade that controls cellular proliferation, differentiation, and survival in response to …
Ras-Mediated Activation of the Raf Family Kinases - PMC
The Raf kinases interact directly with active, membrane-localized Ras, and this interaction is often the first step in the Raf activation process, which ultimately results in ERK activation and the …
A Structure is Worth a Thousand Words: New Insights for RAS and RAF ...
2022年4月1日 · These structures provide key insights regarding RAS and RAF regulation as well as promising new strategies for therapeutic intervention. Significance: The RAS GTPases are …
靶向RAS–ERK信号通路的癌症治疗 - 梅斯医学MedSci
2025年2月18日 · ras-raf-mek-erk（简称erk信号通路）是调控细胞增殖与存活的核心通路，其异常活化与多种癌症的发生发展密切相关。在生理条件下，该通路通过多级反馈调控维持稳态，但 …