2024年12月25日 · RASSF5 (Ras Association Domain Family Member 5) is a Protein Coding gene. Diseases associated with RASSF5 include Leukocyte Adhesion Deficiency, Type I and …

ERK进入细胞核后直接磷酸化转录因子Elk-1的多个位点，如Ser383 和 Ser389 等。 磷酸化后的Elk-1构象发生改变，与血清反应因子（SRF）的相互作用，形成高活性的转录因子复合物。

2021年12月1日 · We show that upon introduction into A549 lung carcinoma cells, the engineered RASSF5 mutants decreased cell viability and mobility to a significantly greater extent than WT …

2016年12月1日 · We argue that in vivo activated RASSF5 can function to activate MST1/2 and suppress cancer (Figure 1 a) whereas in vitro, activated RASSF5 can function to inhibit …

2009年12月1日 · It was suggested that, based on their studies, RASSF5A alone does not induce apoptosis, but it was said that RASSF5 is a cytoskeletal protein that suppresses cell growth by …

Ras association domain-containing protein 5 is a protein that in humans is encoded by the RASSF5 or F5 gene. [5][6][7] This gene is a member of the Ras association domain family. It …

2021年10月27日 · In this study we present a high-affinity inhibitor of Ras based on the RA domain of a natural Ras effector, R as A ssociation Domain F amily 5 (RASSF5) (Fig. 1B). RASSF5 …

2017年3月1日 · Using all-atom molecular dynamics simulations, we modeled the RASSF5 RA with a covalently connected SARAH to elucidate the dynamic mechanism of how SARAH …

Broad expression in bone marrow (RPKM 44.1), lymph node (RPKM 34.6) and 20 other tissues. 该基因是 Ras 关联域家族的成员。 它起到肿瘤抑制因子的作用，并在多种癌症中失活。 编码 …

2010年11月5日 · Here, we show that RASSF5 plays an important role in mediating apoptosis in response to death receptor ligands, TNF-α and TNF-related apoptosis-inducing ligand. …