2012年1月1日 · The nuclear Rat1/Xrn2, together with the cytoplasmic Xrn1, constitutes the XRN family of conserved exonucleases that is unique for eukaryotic organisms.

5'-3' Exoribonuclease 2 (XRN2) also known as Dhm1-like protein is an exoribonuclease enzyme that in humans is encoded by the XRN2 gene. [5] The human gene encoding XRN2 shares …

2025年2月6日 · The 5′–3′ exoribonuclease Xrn2, known as Rat1 in yeasts, terminates mRNA transcription by RNA polymerase II (RNAPII). In the torpedo model of termination, the activity …

2012年12月31日 · Despite many years of extensive research and recent findings related to the structure and function of these enzymes revealed almost every year, several aspects are yet …

2024年9月8日 · The yeast Rat1 protein (Xrn2 in humans) is an essential 5´–3´-exoribonuclease responsible for this final step 22,23,24,25. Rat1 forms a binary complex with Rai1, a partner …

2015年11月10日 · Dhp1 is a conserved and essential protein related to Saccharomyces cerevisiae Rat1 and human Xrn2 that is implicated in coupling 3′-end processing to …

RNA interference (RNAi) of the human 5ʹ-3ʹ exonuclease, Xrn2, or mutation of its budding yeast equivalent, Rat1, was originally shown to disrupt termination on transfected plasmids and …

2020年8月28日 · Persistent R-loops (RNA–DNA hybrids with a displaced single-stranded DNA) create DNA damage and lead to genomic instability. The 5′-3′-exoribonuclease 2 (XRN2) …

2024年12月25日 · XRN2 (5'-3' Exoribonuclease 2) is a Protein Coding gene. Diseases associated with XRN2 include Amyotrophic Lateral Sclerosis 4, Juvenile and Spinocerebellar Ataxia, …

XRN2 (D6L5F) Rabbit mAb recognizes endogenous levels of total XRN2 protein. Human, Mouse, Rat, Monkey. Monoclonal antibody is produced by immunizing animals with a synthetic peptide …