2024年12月25日 · RBBP4 (RB Binding Protein 4, Chromatin Remodeling Factor) is a Protein Coding gene. Diseases associated with RBBP4 include Retinoblastoma and Corneal Argyrosis. Among its related pathways are RNA Polymerase I Promoter Opening and …

2023年6月23日 · Here, we show that the histone chaperone RBBP4, but not its homolog RBBP7, is indispensable for maintaining the identity of mouse embryonic stem cells (mESCs). Auxin-induced degradation of RBBP4, but not RBBP7, reprograms mESCs to the totipotent 2C-like cells. Also, loss of RBBP4 enhances transition from mESCs to trophoblast cells.

Histone-binding protein RBBP4 (also known as RbAp48, or NURF55) is a protein that in humans is encoded by the RBBP4 gene. [5][6] This gene encodes a ubiquitously expressed nuclear protein that belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly.

RBBP4 depletion leads to the loss of the heterochromatin marks and activation of TEs and 2C genes. Together, our findings illustrate that RBBP4 is required for heterochromatin assembly and is a critical barrier for inducing cell fate transition from pluripotency to totipotency.

该基因编码一种普遍表达的核蛋白，属于 WD 重复蛋白的高度保守亚家族。 它存在于参与组蛋白乙酰化和染色质组装的蛋白质复合物中。 它是 Mi-2 复合体的一部分，与组蛋白去乙酰化相关的染色质重塑和转录抑制有关。 这种编码的蛋白质也是共抑制复合物的一部分，它是转录沉默的一个组成部分。 它存在于几种直接结合视网膜母细胞瘤蛋白以调节细胞增殖的细胞蛋白中。 这种蛋白质似乎也参与了 E2F 反应基因的转录抑制。 已发现该基因的三个转录变体编码不同的亚型。 …

In NSCLC, RBBP4 upregulation correlates with poor prognosis and altered immunity. Its knockdown induces autophagic cell death in NSCLC cells. These results indicate RBBP4 as a potential NSCLC diagnostic marker and its autophagy modulation as a …

RBBP4, also known as RbAp48 or NURF55, is integral to multiple chromatin-modifying and remodeling complexes. It was originally discovered as a binding partner of the tumor suppressor retinoblastoma protein (RB) in yeast (16), and subsequently revealed to cofractionate with histone deacetylase (HDAC)1 (17).

Retinoblastoma-binding protein (RBBP) family is a class of proteins that can interact with tumor suppressor retinoblastoma protein (pRb). RBBP4 and RBBP7 are the only pair of homologous proteins in this family, serving as scaffold proteins whose main function is to offer a platform to indirectly connect two proteins.

RBBP4 plays a vital role in the malignant progression of triple-negative breast cancer by regulating epithelial-mesenchymal transition. RBBP4-p300 axis modulates expression of genes essential for cell survival and is a potential target for therapy in glioblastoma.

2021年3月9日 · Here, we show that deficiency of retinoblastoma binding protein 4 (RBBP4), a component of the Polycomb repressive complex 2 (PRC2), in embryonic stem cells (ESCs) leads to spontaneous differentiation into mesendodermal lineages.