RNA-dependent RNA polymerase (RdRp) or RNA replicase is an enzyme that catalyzes the replication of RNA from an RNA template. Specifically, it catalyzes synthesis of the RNA strand complementary to a given RNA template.

病毒RNA复制酶，也称RNA依赖的RNA聚合酶（RNA-dependent RNA polymerase, RdRp）负责RNA病毒基因组的复制和转录，在病毒在宿主细胞中的自我复制过程中扮演着非常重要的作用。

2021年11月25日 · The central enzyme of transcription and replication is the RNA-dependent RNA polymerase (RdRp), which synthesizes all viral RNA and is a proven target for antiviral drugs.

2022年2月15日 · RdRp are proteins that are involved in the replication of RNA-based viruses. Inhibition of RdRps has been an integral approach for managing various viral infections such as dengue, influenza, HCV (Hepatitis), BVDV, etc. Inhibition of the coronavirus RdRp is currently rigorously explored for the treatment of Covid-19 related complications.

RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA viruses that is indispensable for replicating the genome as well as for carrying out transcription. The core structural features of RdRps are conserved, despite the divergence in their sequences.

RNA依赖RNA聚合酶（RdRp，又称nsp12）在病毒内催化病毒RNA的合成，它也是冠状病毒复制的核心组成部分，也是一个抗病毒药物例如瑞德西韦的主要靶点。

Under physiological conditions, RNA-dependent RNA polymerases (RdRPs) catalyze the formation of phosphodiester bonds between ribonucleotides in an RNA template-dependent fashion. RdRPs have been found primarily in RNA viruses.

2018年1月4日 · Viral RNA-dependent RNA polymerase nucleotide addition cycle (RdRP NAC) states. Seven RdRP EC models represent NAC reference states 1–6 and an intermediate state between states 2 and 3. Each model corresponds to a Scene in the PyMOL assembly (Supplementary file 1) that can be conveniently recalled in the PyMOL interface.

2021年1月29日 · Remdesivir targets the RNA-dependent RNA polymerase (RdRp), an essential enzyme for viral RNA replication and a promising drug target for COVID-19. Recently, several structures of RdRp in complex with substrate RNA and remdesivir were reported, providing insights into the mechanisms of RNA recognition by RdRp.

2020年5月25日 · RNA 病毒是一类独特的生命形式，其基因组复制过程完全不涉及 DNA 形式，因此需要自身编码的依赖 RNA 的 RNA 聚合酶（ RNA-dependent RNA polymerase ，简称 RdRP ）来主导完成。