2019年10月31日 · Recombinases are responsible for homologous recombination and maintenance of genome integrity. In Escherichia coli, the recombinase RecA forms a nucleoprotein filament with the ssDNA present at a DNA break and searches for a homologous dsDNA to use as a template for break repair.

4 天之前 · The Radiation Exposure Compensation Act (“the Act” or “RECA”), 42 U.S.C. § 2210 note, established an administrative program for claims relating to atmospheric nuclear testing and uranium industry employment. The Act delegated authority to the Attorney General to establish procedures and make determinations regarding whether claims ...

RecA是大肠杆菌中recA基因座的产物，具有双重功能，能激活蛋白酶并能改变单链DNA分子。 RecA蛋白是一种多功能蛋白质，它参与大肠杆菌所有的同源重组途径，有单体和多聚体两种形式。

RecA is a 38 kilodalton protein essential for the repair and maintenance of DNA in bacteria. [2] Structural and functional homologs to RecA have been found in all kingdoms of life. [3] [4] RecA serves as an archetype for this class of homologous DNA repair proteins. The homologous protein is called RAD51 in eukaryotes and RadA in archaea. [5] [6]

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2021年10月26日 · In this work, we studied the biological properties of seven RecA variants, in particular their recombinogenic activity and their ability to induce the SOS response, to better understand the...

2008年5月22日 · RecA, ATP and single-stranded DNA (ssDNA) form a helical filament that binds to double-stranded DNA (dsDNA), searches for homology, and then catalyses the exchange of the complementary strand,...

2021年9月2日 · 利用荧光显微镜，Elf团队实时调查了断裂位点及其同源DNA拷贝的命运。他们还发现，细菌细胞的反应是重新排列RecA，使之形成横跨细胞长度的细丝。

RecA蛋白能特异地识别单链DNA，并能将之与同源双螺旋中的互补顺序“退火”，同时将另一条链排挤出去，形成所谓D环（D－LOOP）。 RecA蛋白首先与单链DNA结合（约每分子可结合5个核苷酸），形成一条DNA－蛋白质细丝（需消耗ATP）。 于是RecA蛋白即被活化而可将双螺旋解旋和分离，同时企图将它结合的单链与被解旋区域退火，如此继续下去，直到找到互补顺序。 只要一旦有一小部份被真正“退火”，ATP供应的能量就会继续驱使配对反应趋于完成，其方向是5’→3’（ …

The bacterial RecA protein is the prototypical recombinase, promoting the central steps of DNA pairing and strand exchange in genetic recombination and recombinational DNA repair. RecA homologs are present in virtually all organisms from bacteria to …