Receptor tyrosine kinases (RTKs) are essential components of signal transduction pathways that mediate cell-to-cell communication. These single-pass transmembrane receptors, which bind polypeptide ligands — mainly growth factors — play key roles in ...

2025年2月10日 · Receptor Tyrosine Kinase (RTK) pathways are crucial for transmitting signals from the cell surface to intracellular targets, influencing cellular processes like growth, differentiation, and metabolism.

An example of a vital signal transduction pathway involves the tyrosine kinase receptor, c-met, which is required for the survival and proliferation of migrating myoblasts during myogenesis. A lack of c-met disrupts secondary myogenesis and—as in LBX1—prevents the formation of …

2023年8月31日 · When a signal arrives at the receptor tyrosine kinase, the receptor monomers come together and phosphorylate each others' tyrosines, triggering the assembly of a complex of proteins on the cytoplasmic tail of the receptor.

2022年9月26日 · Receptor tyrosine kinases (RTKs) constitute one class of transmembrane receptors and are characterized by their cytoplasmic regions' intrinsic tyrosine kinase activity. Signal transduction is how an electrical, physical, or chemical signal elicits a cellular response by activating a cellular receptor and initiating a chain of biochemical events.

2019年1月17日 · Common signaling pathways activated downstream of RTK activation include RAF/MAP kinase cascades (reviewed in McKay and Morrison, 2007 and Wellbrock et al 2004), AKT signaling (reviewed in Manning and Cantley, 2007) and PLC-gamma mediated signaling (reviewed in Patterson et al).

2024年1月12日 · The tyrosine kinase receptor, c-met, is an illustration of a crucial signal transduction pathway that is necessary for the survival and proliferation of migratory myoblasts during myogenesis. Lack of c-met impairs secondary myogenesis and, like LBX1, hinders the development of limb musculature.

We examine prevailing concepts that underlie the activation of intracellular signaling pathways following growth factor binding to RTKs. We also consider recent systems biology approaches for understanding the complicated circuits and networks that result from the interplay among the multiple signaling pathways activated by RTKs.

Most receptor tyrosine kinases are single-pass, transmembrane proteins that bind extracellular polypeptide ligands (i.e. growth factors) and cytoplasmic effector and adaptor proteins to regulate biological processes. Ligand binding promotes receptor dimerization and autophosphorylation of receptor tyrosine residues.

Knowledge of the cascade of biochemical events triggered by ligand stimulation of tyrosine kinase receptors has increased rapidly and has provided further evidence of the importance of their signaling pathways in cancer.