most frequent constitutional translocation in humans, the t (11;22 ...
Jun 12, 2000 · The t(11;22) is the most common recurrent non-Robertsonian constitutional translocation in humans, having been reported in more than 160 unrelated families. Balanced carriers are at risk of having offspring with the derivative 22 syndrome owing to 3:1 meiotic non-disjunction event.
The 11/22 Translocation - Emanuel Syndrome
A reciprocal translocation means that there is a two-way exchange of information between these two chromosomes. Nothing is missing and nothing is extra, thus making a carrier of this translocation “balanced” in terms of genetic information.
In people with the 11;22 translocation, the bottom bit of one chromosome 11 (a medium-sized chromosome) has transferred to chromosome 22 (a small chromosome) and the bottom bit of one chromosome 22 has moved to chromosome 11.
Reciprocal Chromosome Translocation - an overview
Reciprocal chromosome translocations are defined as the reciprocal exchange of genetic material between two chromosomes, with a break point in each of them. This exchange can be balanced, if all chromosomal material is preserved; or unbalanced, if there has been gain and/or loss of chromosomal material in one or both chromosomes involved.
Site-specific reciprocal translocation, t(11;22) (q23;q11), in …
We have studied 32 unrelated families with a site-specific reciprocal translocation between chromosomes 11 and 22 [t (11;22) (q23;q11)]. In translocation heterozygotes 3:1 meiotic segregation occurs and results in abnormal progeny who carry the der (22) as a …
AT-Rich Palindromes Mediate the Constitutional t(11;22) Translocation
The LCR22s contain AT-rich repetitive sequences, suggesting that such repeats may mediate the t(11;22) translocation. To determine the molecular basis of the translocation, we cloned and sequenced the t(11;22) breakpoint in the derivative 11 and 22 chromosomes in 13 unrelated carriers, including two de novo cases and der(22) syndrome offspring.
chromosome 22 in band qll are numerous and found to be (1), which involves the same chromosomal regions. The associated with a diversity of neoplasms as well as constitutional constitutional t(11;22)(q23;qll) is a site-specific, reciprocal disorders.
Precise location of breakpoints in a frequent reciprocal translocation ...
One of the most frequent chromosomal translocations in human beings is 11q/22q, which results in the "partial trisomy of 22q syndrome." However, the breakpoint on the long arms of chromosomes 11 and 22 is still a matter of controversy. In the present study, we have used chromosomes from lymphocytes …
A Common Breakpoint on 11q23 in Carriers of the Constitutional t(11;22 …
Nov 18, 1999 · To determine the molecular basis of the reciprocal t (11;22) translocation in the normal carrier parents, it is necessary to characterize the breakpoint intervals on 11q23 and 22q11.
Comparison of constitutional and tumor-associated 11;22 translocations ...
Chromosome 11 in bands q23-q24 is similarly involved in several types of tumors as well as in a recurring constitutional reciprocal translocation with chromosome 22. Here we report the use of chromosomal in situ hybridization to compare the translocation breakpoints in the cytologically indistinguishable constitutional t(11;22) and the tumor ...