REDD2 is a Unique Skeletal Muscle-Specific Negative Regulator of mTOR Signaling. REDD2, also known as SMHS1/RTP801L/DDIT4L, was recently identified in a subtractive hybridization screen as one of the most highly upregulated genes in …

2014年9月26日 · Short interfering RNA-mediated REDD2 knockdown restored mTOR activity and rescued dendritic length, area and branch complexity in a rapamycin-dependent manner. Whole-cell recordings demonstrated...

DNA-damage-inducible transcript 4 like (DDIT4L) or regulated in development and DNA damage response 2 (REDD2) is a protein that in humans is encoded by the DDIT4L gene. [5] [6] The gene is located on chromosome 4 or chromosome 3 in human or mouse respectively. [7] [8]

Short interfering RNA-mediated REDD2 knockdown restored mTOR activity and rescued dendritic length, area and branch complexity in a rapamycin-dependent manner. Whole-cell recordings demonstrated...

In this study, we determined that the stress responsive gene REDD2 (regulated in development and DNA damage responses 2) is a negative regulator of mTOR signaling and is expressed predominantly in skeletal muscle.

2013年1月1日 · Inhibitory signals mediated by p53, Sestrins , AMP-activated protein kinase (AMPK) , regulated in development and DNA damage response (REDD) 1 , and REDD2 attenuate mTORC1 signaling and rates of protein synthesis.

2014年2月25日 · Soleus immobilized in a shortened position exhibited disuse atrophy, attenuated rates of protein synthesis, attenuated mTORC1 signaling, and induced expression of genes for REDD1, REDD2, MAFbx, and MuRF1.

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2009年3月1日 · REDD2 is a Unique Skeletal Muscle-Specific Negative Regulator of mTOR Signaling. REDD2, also known as SMHS1/RTP801L/DDIT4L, was recently identified in a subtractive hybridization screen as one of the most highly upregulated genes in the soleus muscle following hindlimb unloading .

2015年1月1日 · Regulated in development and DNA-damage response (REDD) 2, but not REDD1, mRNA expression increases with age and becomes unresponsive to immobilization, but is repressed following remobilization. REDD1 and REDD2 mRNA expression in the soleus muscle was assessed by Taqman gene expression assay.