2021年9月16日 · The term reactive oxygen species (ROS) describes a set of distinct molecular oxygen derivatives produced during normal aerobic metabolism. Multiple ROS-generating and ROS-eliminating systems actively maintain the intracellular redox state, which serves to mediate redox signaling and regulate cellular functions.

2014年5月19日 · Redox biology involves a small increase in ROS levels that activates signaling pathways to initiate biological processes, while oxidative stress denotes high levels of ROS that result in damage to DNA, protein or lipids.

2022年2月21日 · Use of precise definitions and analytical tools will help harmonize research among the many scientific disciplines working on the common goal of understanding redox biology. ‘Reactive oxygen...

Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. Oxidative stress refers to the imbalance due to excess ROS or oxidants over the capability of the cell to mount an effective antioxidant response.

Reactive oxygen species (ROS) homeostatic pathways in microbes operate instant and feedback-regulated adjustments of intracellular ROS concentration. They use redox sensors that 'measure'...

2020年3月30日 · In this Review, we address ROS generation and its regulation with focus on H 2 O 2 and O 2·−, their mechanisms of redox signalling, major molecular physiological redox targets and associated...

2024年3月1日 · ROS-mediated activation of redox-sensitive signaling pathways, such as nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK), promotes tumor cell proliferation, survival, angiogenesis and metastasis [150].

2025年3月23日 · Nanovesicle membranes facilitate the stable accumulation of nanozymes with homologous targeting, recognition, and endocytosis, effectively addressing the potentially high toxicity and off-target defects. Therefore, the outcome of the in situ ROS-bloom acts as a redox signal for directly regulating oxidative stress in the tumor microenvironment.

The term redox signaling refers to the process wherein ROS or related reactive species act as second messengers to cause physiological cellular responses via redox reactions.

Redox biology refers to low levels of ROS that activate signaling pathways to initiate biological processes while oxidative stress denotes high levels of ROS that incur damage to DNA, protein or lipids.