2024年12月25日 · RELT (RELT TNF Receptor) is a Protein Coding gene. Diseases associated with RELT include Amelogenesis Imperfecta, Type Iiic and Amelogenesis Imperfecta, Type Ie . Among its related pathways is TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions .

Tumor necrosis factor receptor superfamily member 19L is a protein that in humans is encoded by the RELT gene. [5] [6] [7] [8] [9]

RELT 肿瘤坏死因子受体： 由该基因编码的蛋白质是 TNF 受体超家族的成员。这种受体在血液组织中特别丰富。它已被证明可以激活 NF-kappaB 通路并选择性地结合 TNF 受体相关因子 1 (TRAF1) 。

2023年10月2日 · This review highlights Receptor Expressed in Lymphoid Tissues (RELT), a Tumor Necrosis Factor Superfamily member, and its two paralogs, RELL1 and RELL2. Collectively, these three proteins are referred to as RELTfms and have gained much interest in recent years due to their association with cancer and other human diseases.

1975年，发现一种细菌诱导的循环因子对植入小鼠皮肤的肿瘤具有很强的抗肿瘤活性，称其为肿瘤坏死因子（TNF），随后该基因被分离，克隆，成为一个与免疫调节和炎症有关的分子家族的原型。 在哺乳动物中， TNF配体超家族 （TNFSF）通过TNF受体超家族（TNFRSF）的成员发出信号，激活在发育、器官发生、细胞死亡和存活中生物学作用的信号通路。 最早发现的TNFSF成员是TNF和淋巴毒素α（Ltα）。 随着人类和小鼠基因组大规模测序的完成，几乎所有的TNFSF …

在淋巴组织中表达的受体（relt）是人类肿瘤坏死因子受体（tnfr）家族成员，具有两个已鉴定的同源结合伴侣rell1和rell2。这项研究试图进一步了解relt表达的模式，relt家族成员的功能作用以及relt诱导的细胞凋亡的机制。

2001年5月1日 · RELT is able to activate the NF-κB pathway and selectively binds tumor necrosis factor receptor-associated factor 1. Although the soluble form of RELT fusion protein does not inhibit the one-way mixed lymphocyte reaction, immobilized RELT is capable of costimulating T-cell proliferation in the presence of CD3 signaling.

RELT (tumor necrosis factor receptor superfamily member 19-like, TNFRSF19L) is a TNFR superfamily member that is primarily expressed in immune cells and lymphoid tissues, but whose immunological function is not well-defined. Here, we show that RELT is expressed by naive T cells and DCs, and their activation or maturation decreases RELT expression.

2001年5月1日 · This study reports the cloning of a new member of the TNFR superfamily, RELT (Receptor Expressed in Lymphoid Tissues). RELT is a type I transmembrane glycoprotein with a cysteine-rich extracellular domain, possessing significant homology to other members of the TNFR superfamily, especially TNFRSF19, DR3, OX40, and LTbeta receptor.

2024年11月27日 · RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB. Sica GL, Zhu G, Tamada K, Liu D, Ni J, Chen LSica GL, et al .